孕妇血清唾液酸与正常新生儿的体格生长

Effects of serum sialic acid in pregnant women on neonatal physical growth

【目的】研究孕妇不同妊娠期的血清唾液酸含量、脐血清唾液酸含量、唾液酸胎盘转运率与新生儿体格生长的关系。【方法】采取前瞻性队列研究的方法,从妊早、中、晚期至分娩时,分析孕期血清唾液酸水平与子代出生体重、身长、头围和Kaup指数的关系。【结果】妊早、中、晚期孕妇不同血清唾液酸含量的新生儿出生体重、出生身长、出生头围及Kaup指数差异均无统计学意义(P>0.05);不同脐血清唾液酸和唾液酸胎盘转运率的新生儿出生体格差异亦无统计学意义(P>0.05)。【结论】妊娠期的唾液酸含量、新生儿脐唾液酸含量和唾液酸胎盘运转率对新生儿出生体格生长无显著影响,唾液酸不会对婴儿造成肥胖的影响,唾液酸胎盘转运率只是反映唾液酸通过胎盘的一个度量,可以衡量胎儿当时生长发育的营养需求。

[Objective] To investigate the correlation between the maternal serum sialic acid （SA） contents,umbilical cord serum SA contents,SA placenta transport rate with infant early growth and development. [Methods] Prospective cohort study was carried from early pregnancy, followed up to middle,late pregnancy and delivery. The relationships between maternal serum sialic acid at three stages of pregnancy, with offspring birth weight, height, head circumference and Kaup in- dex were carried out. [Results] There were no significant differences in the neonatal birth weight, birth length, birth head circumference and Kaup index respectively in different serum SA contents in early pregnancy, middle pregnancy and late pregnancy（P^0.05）. And there were no significant differences of umbilical cord serum SA and SA placenta transfer rate on neonatal outcome either（P~〉0.05）. [Conelusiens] There are no significant effects of maternal serum SA contents during pregnancy, fetal umbilical cord SA levels and SA placenta transfer rate on birth physical growth. SA doesn＇t cause obesity to infants. SA placenta transport rate can reflect the nutritional needs for fetal growth and development.