新生儿时期食物特异性IgG检测的临床意义

Clinical significance of food intolerance-specific IgG antibody detection in neonates

【目的】测定疑似新生儿时期出现食物不耐受症状的患儿血清特异性IgG抗体,并对影响特异性IgG抗体结果的相关因素进行分析,探讨特异性IgG抗体在检测新生儿食物不耐受中的意义及新生儿食物不耐受发生的可疑危险因素。【方法】应用酶联免疫法检测临床疑似出现食物(主要是牛奶蛋白)不耐受症状的60例患儿及对照组60例新生儿血清特异性IgG抗体;采用Logistic回归模型分析影响特异性IgG抗体结果的相关因素。【结果】93.3%患儿存在不同种类食物过敏原特异性IgG升高,6项指标单因素分析中有3项指标具有显著性意义(P<0.05);其中2项指标被选入Logistic回归方程(P均<0.05)。过敏性疾病家族史的OR值为3.170(95%CI:1.240～8.103),母乳喂养的OR值为0.359(95%CI:0.157～0.822);未发现新生儿性别、分娩方式、胎龄、母孕期吸烟情况等与食物IgG抗体结果有关。【结论】食物不耐受在新生儿时期就可表现出一系列症状,其中特异性IgG抗体检测具有较高阳性率;母乳喂养是新生儿食物不耐受IgG抗体阳性结果的保护因素,家族过敏史是其危险因素;对新生儿时期出现食物不耐受情况提高意识,及早诊断,予以干预,避免对以后生长发育产生严重影响。

[Objective] To ascertain the significance of food intolerance-specific IgG antibody detection and suspicious risk factors of food intolerance in neonates. [MethodsI The food intolerance-specific IgG antibodies in serum were meas- ured by Enzyme-Linked Immunosorbnent Assay （ELISA） in 60 neonates who were considered to be food intolerance（espe- cially cow＇s milk） and in 60 control neonates,analyzed the influential factors of IgG results by Logistic regression models. [ResultsI 93.3% of patients appeared positive results in different food IgG antibodies ~ In the single factor analysis,3 inde- xes were obviously significant （P（O. 05） and 2 of them were also significant in the multi-factor stepwise regression analysis （P〈0.05） There were no relationships between the sex,delivery ways, gestational age, smoking during pregnancy and the result of IgG results. [ConclusionsI Neonates can show a series of food intolerance symptoms in the neonatal period and specific IgG antibody detection has higher positive rate. The results indicate that family history of atopic diseases was the risk factor of specific IgG positive result,while breast feeding was protective. Raising awareness for food intolerance of neo- nates,and intervention should be given to avoid a serious effect on growth as early as possible.