2012年广州地区25295名儿童维生素D营养状况分析

Study on vitamin D nutritional status among 25 295 children in Guangzhou area in 2012

【目的】分析广州地区25 295名儿童维生素D营养状况与年龄、季节的关系。【方法】采用酶联免疫法检测25-羟基维生素D[25-(OH)D]水平,收集2012年全年广州市妇女儿童医疗中心25 295例0～16周岁健康儿童25-(OH)D结果,维生素D营养状况以血清水平判断:维生素D严重缺乏(<12.5nmol/L)、维生素D缺乏(12.5～37.5nmol/L)、维生素D不足(37.5～50.0nmol/L),分别各年龄组及各月份应用SPSS 17.0统计软件进行分析。【结果】2012年广州地区25 295例儿童25-(OH)D平均水平72.41nmol/L,无性别差异;无维生素D严重缺乏病例;25-(OH)D<50nmol/L的比例为13.22%。儿童25-(OH)D水平随年龄的增长而降低,维生素D的缺乏和不足与年龄呈正比;2012年1月份为全年最低水平,1～7月份25-(OH)D水平逐月上升,8、9月份达到全年峰值,10～12月份逐月下降;各月份维生素D缺乏和不足的比例在1月份为全年最高,全年最低值在9月份。【结论】广州地区在冬春季节儿童维生素D营养水平较低,3周岁以上的儿童维生素D营养缺乏较严重。

[Objective] To analyze vitamin D nutritional status among 25 295 children in Guangzhou area and investi- gate its correlation with age and season. [Methods] The serum samples of healthy children from Guangzhou Women and Children＇s Medical Center in 2012 were tested. Serum 25-hydroxyvitamin D[25-（OH）D] concentration was determined by ELISA kits. Serum Vitamin D status was classified into 3 groups according to its serum 25-（OH）D levels,severe deficiency （〈12.5 nmol/L）,deficiency（12.5-37.5 nmol/L） and insufficiency（37.5-50.0 nmol/L）. Statistical analysis were done with SPSS 17.0 software. [Results] Totally, 25 295 children samples were detected in 2012. The average serum 25- （OH）D concentration was 72.41 nmol/L. No significant correlation was found between the serum 25-（OH）D concentration and gender. Severe deficiency case was not found. The vitamin D concentration 〈50 nmol/L was 13.22%. The 25-（OH）D concentration decreased with age. The lowest concentration of vitamin D was found in Jan 2012. Then it increased gradually from Jan. to July, peaking in Aug. and Sep. and slow declined. Meanwhile, he vitamin D deficiency and insufficiency rate was peaking in Jan. and lowest in Sep.. [Conclusion] The vitamin D concentration is lower in autumn and winter. The vitamin D nutritional status of children over 3 years old in Guangzhou is deficiency.