兰州地区儿童幽门螺杆菌感染864例状况分析

Analysis of related factors of helicobacter pylori infections in 864 children in Lanzhou

【目的】了解儿童幽门螺杆菌(helicobacter pylori,Hp)感染的现状及特点,为进一步做好预防工作提供科学依据。【方法】对864例2007年5月-2011年5月门诊或住院的有消化道症状的儿童,年龄2～15岁,在研究开始时,进行Assure R幽门螺杆菌感染血清学快速筛查,阳性者进行粪便Hp抗原测定,最后对结果进行统计学分析。【结果】864例2～15岁儿童Hp检出率为30.9%,其中男、女分别为29.9%和30.9%。Hp检出率总体趋势随年龄增长而增长,但不均衡,以13～15岁检出率最高,父母有胃十二指肠病史的儿童Hp检出率明显高于父母无胃十二指肠病史者,差异有统计学意义。城乡儿童中Hp检出率差异有统计学意义。【结论】本院2～15岁儿童Hp检出率处于较高水平,在性别方面无差异,Hp感染有明显家庭聚集性和明显的城乡差别,并随着年龄增加,Hp检出率呈逐渐升高趋势。

[Objective] To analyze the related factors of helieobaeter pylori（Hp） infections in children,and provide theory basis for prevention. [Methods] A total of 864 eases,aged 2 to 15 years old outpatient or hospitalized children with gastrointestinal symptoms in May 2007-May 2011, received the study of Hp infection assure R rapid serological screen- ing positive for Hp stool antigen determination. [Results] Hp infection rate for children aged 2-15 in Lanzhou was 30. 4%, the percentages of infection for male and female were 29.9% and 30.9%, respectively. There had an irregular increasing trend of Hp infection rate with the increasing of age,and the group aged 13-15 showed the highest infection rate. Hp infec- tion rate of children whose parents had a history of gastroduodenal diseases was significantly higher than children whose par- ents without a history of gastroduodenal diseases. There had statistical differences. Hp infection in children in urban and ru ral had significant differences. [Conclusions] Hp infection rates for children aged 2-15 are at the higher level,and there are no difference between girls and boys. Hp infection was irregular increasing with the increasing of age. Family aggregation of Hp infection was shown in this study.