超声检测心外膜脂肪组织厚度与冠心病严重程度的相关性研究

Study on the relationship between echocardiographic epicardial fat thickness and the severity of coronaryheart disease

目的应用经胸超声测量心外膜脂肪组织厚度（EAT）与冠心病发生及其严重程度的相关性。方法将80例行冠状动脉造影患者根据冠状动脉造影结果是否有冠心病分为有冠心病组（简称冠心病组，46例）和无冠心病组（简称对照组，34例），并根据冠状动脉病变程度将冠心病组分为单支病变亚组（24例）、多支病变亚组（22例）。采集研究对象经胸超声图像，于心脏收缩末期。左心长轴切面测量右室游离壁前方的EAT。并将其与冠心病的相关危险因素（如年龄、性别、血脂水平、高血压、糖尿病、吸烟、冠心病家族史）及冠状动脉病变严重程度进行相关性分析。结果冠心病多支病变患者的EAT[（8．85±1，44）mm]明显高于单支病变患者[（6．86±1．09）mm]及对照组[（4．58±1．12）mm]（均P〈0.01）；EAT与冠心病的相关危险因素明显相关（P〈0．05）。经均衡年龄、血糖、血压等其它危险因素后，EAT仍是冠心病发生的独立危险因素（OR：5．394，95％CI：1．700-17．112，P=0．004）。结论EAT与冠心病的发生及其严重程度有显著的相关性。

Objective To investigate the correlation between epicardial fat thicktless （EAT） and the risk factors of coronary artery disease （CAD） as well as the severity of coronary lesions with echocardiography. Methods According to the results of coronary angiography,80 patients underwent coronary angiography were divided into coronary heart disease group （ CHD group, 4 6 cases ） and without coronary heart disease group （ control group, 3 4cases） ,and according to coronary arterythe severity, CHD group was divided into subgroups of single-vessel disease （24 cases） and multivessel disease subgroup （22 cases）, The epicardial fat thickness on the free wall of the right ven- tricle was measured at end-systole from the para-stemal long-axis views, The relationship between EAT and the risk factors of CAD （ such as age, gender, hypercholesterolemia, hypertension, diabetes, smoking, family CAD history） as well as theseverity of coronary lesions were analyzed. Results EAT in rmiltivessel disease CAD group [ （ 8.85 ± 1, 44）mini was significantly higher than that in single vessel CAD groupC （6, 86 ± 1, 09） mm] and control group [ （4.58±1. 12）mm] （all P 〈0.01 ）, EAT was significantly related with the risk factors of CAD. Although the risk factors of GAD such as age, blood glucose, blood pressure were adjusted, EAT was still independently associated with CAD（OR：5.394,95% CI：1.700 ± 17.112,P-0, QQ4）. Conclusion The level of EAT is significantly correlated with CAD and the severity of coronary lesions.