保留灌肠防治放射性直肠炎

Prevention and treatment of radiation proctitis by retention enema

目的探讨保留灌肠对放射性直肠炎的防治效果。方法将120例盆腔恶性肿瘤放疗患者按数字表随机分为两组，每组60例。观察组放疗后2-14d开始保留灌肠，每天1次。对照组放疗后期当患者出现放射性直肠炎时，开始保留灌肠，每天1次。观察两组患者放疗期间放射性直肠炎的发生率及严重程度。结果观察组放射性直肠炎发生率为35．0％，明显低于对照组的83．3％（X^2=47．623，P=0．000）；观察组Ⅱ、Ⅲ度放射性直肠炎发生率分别为3．3％、0，均低于对照组的26．7％、6．7％（X^2=12．810、4．138，P=0．000、0．042）；观察组总有效率为100．0％，明显高于对照组的72．0％（X^2=32．558，P=0．000）。结论保留灌肠能有效治疗放射性直肠炎，放疗后即开始行保留灌肠，效果更加显著。

Objective To study the effect of prevention and treatment for patients with radiation proctitis by retention enema. Methods According to the digital table, 120 patients with pelvic tumor treated with radiotherapy were randomly divided into two groups. The observation group was taken retention enema 2 to lg days after radiothera- py once a day. The control group was taken retention enema when the patients with radiation proctitis after radiothera- py. The severity and frequency of radiation proctitis were observed in the two groups. Results The incidence of radia- tion proctitis in the observation group was 35.0%, which was significantly lower than that of the control group （83.3 % ） （X^2 = 47.623, P = 0. 000）. The severity of radiation proctitis was also significantly lower than that of con- trol group. The incidence of Ⅱ and Ⅲ degree of radiation proctitis in the observation group were 3.3% ,0 ,respective- ly,which were significantly lower than those of the control group（26.7% ,6.7% ） （ X^2 = 12. 810,4. 138, P = 0. 000, 0. 042）. The total efficiency rate was 100.0% ,which was significantly higher than that of the control group（72.0% ） （X^2 = 32.558 ,P = 0.000）. Conclusion Retention enema can effectively treat the radiation proctitis and the effect will be more significant if the retention enema starts soon after radiotherapy.