胆道金属支架植入术结合腺苷蛋氨酸治疗恶性梗阻性黄疸伴肝功能损害的疗效观察

Observation of the effect of biliary stenting combined with ademetionine on malignant obstructive jaundice

目的探讨胆道金属支架植入术结合腺苷蛋氨酸治疗恶性梗阻性黄疸的疗效。方法将60例恶性梗阻性黄疸患者按数字表法随机分为对照组和观察组；对照组行单纯胆道支架植入术，观察组行胆道支架植入术加腺苷蛋氨酸静脉滴注。分别观察两组肝功能和C反应蛋白情况。结果观察组肝功能指标和C反应蛋白指数情况均显著好于对照组（均P〈0．01）。结论胆道支架植入术结合腺苷蛋氨酸静滴治疗恶性梗阻性黄疸疗效可靠，其机制可能与腺苷蛋氨酸可以修复细胞膜流动性，修复肝细胞；并促进谷胱甘肽合成。清除自由基有关。

Objective To explore the effect of biliary stenting combined with ademetionine on malignant ob- structive jaundice. Methods According to the digital table,60 patients of malignant obstructive jaundice were ran- domly divided into the control group and the observation group. The patients in the control group were treated with bil- iary stenting individually, and the observation group received biliary stenting and combined treatment with ademe- tionine. The variety of liver function and C-reactive protein were observed. Results The liver function and index of C- reactive protein of patients in the observation group were significantly superior to those in the control group （ all P 〈 0. 01 ）. Conclusion The treatment of malignant obstructive jaundice by biliary stenting combined with ademetionine is effective. The mechanism may be related to the effect of ademetionine on promoting cytothesis, glutathione synthesis and eliminating free-radicals.