扶正祛邪联合四联根除方案抗幽门螺杆菌的临床研究

Clinical study on Fuzheng Quxie Formula combined with western medicine in eradicating Helicobacter pylori

[目的]观察以扶正祛邪为主的中药联合抗幽门螺杆菌(Hp)四联根除方案治疗Hp的根除率、症状改善及不良反应发生情况。[方法]以2011年1月～2012年12月在我院治疗的门诊或住院Hp感染患者60例,随机分为观察组和对照组。观察组接受扶正祛邪的中药方剂+四联根除方案,对照组接受单纯四联根除方案,疗程均为7d。比较2两组患者Hp根除率、主要症状改善及不良反应发生率等。[结果]2组患者用药后症状均有好转,观察组患者的上腹痛及反酸改善明显优于对照组(P<0.05);Hp根除率(93.33%)明显高于对照组(73.33%)(P<0.05)。观察组有4例患者发生不良反应,对照组有5例发生不良反应,均未影响后续治疗。[结论]以扶正祛邪为主的中医药联合四联根除方案治疗Hp感染具有明显的优势,可明显提高Hp根除率,明显改善患者的上腹痛和反酸等症状,不良反应小。

[ Objective ] To observe the efficacy and side effect of traditional Chinese medicine combined with western medicine on eradication of Helicobacter pylori（Hp）.[ Methods ] Sixty Hp-infected patients in our hospital were randomly divided into the observation group and the control group.Patients in the observation group received Chinese prescription plus quadruple therapy of western medicine.Meanwhile,patients in the control group only received western medicine.The Hp eradication rates,symptoms and adverse events were recorded.[ Results ] After treatment,patients ’ symptoms were improved in both groups.The upper abdominal pain and acid reflux in observation group improved significantly compared to control group（P0.05）;Hp eradication rate（93.33%） of the observation group was significantly higher than that of the control group（73.33%）（P0.05）.Four cases showed adverse reactions in observation group,while 5cases showed adverse reactions in control group.The subsequent treatment was not interrupted.[ Conclusion ] The traditional Chinese medicine combined with western medicine can significantly improve the H.pylori eradication rate,patient＇s upper abdominal pain and acid reflux symptoms.At the same time,the treatment is safe