康复新液联合胶体果胶铋或(和)奥美拉唑治疗胃溃疡有效性和安全性比较

A randomized,controlled study in the treatment of gastrohelcoma using Kangfuxin liquid combined with colloidal bismuth PECT in-739 and/or omeprazole

[目的]比较康复新液联合胶体果胶铋或(和)奥美拉唑治疗胃溃疡(GU)有效性和安全性。[方法]278例GU患者连续随机地分为:康复新组(A组);康复新+胶体果胶铋组(B组);康复新+奥美拉唑组(C组);康复新+胶体果胶铋+奥美拉唑组(D组)。A组口服康复新治疗,B组在A组的基础上加服胶体果胶铋,C组在A组的基础上加服奥美拉唑;D组在B组的基础上加服奥美拉唑。治疗4周后观察4组患者的腹痛、上腹胀、恶心、呕吐、纳差嗳气、反酸、烧心(或胸骨后烧灼感)等情况及不良反应。[结果]A、B、C、D组治疗后恶心、呕吐改善总有效率分别为50.72%、72.22%、50.74%、75.71%,B、D组与A组,C组与D组比较均差异有统计学意义(P<0.05);A、B、C、D组治疗后腹痛、腹胀改善总有效率分别为52.17%、68.06%、65.67%、95.71%,A、B、C组与D组比较均差异有统计学意义(P<0.05),A组与B组、A组与C组比较差异无统计学意义(P>0.05);A、B、C、D组治疗后反酸、烧心改善总有效率分别为53.62%、80.56%、52.24%、87.14%,B、D组与A组,C组与D组比较均差异有统计学意义(P<0.05)。[结论]单用康复新对GU是有效的,适合轻中度GU;联合胶体果胶铋对GU更有效,适合较重的GU患者;再联合奥美拉唑对于GU最有效,特别适合重型GU患者。

[ Objective ] To compare the efficacy and safety of Kangfuxin Liquid combined with Colloidal Bismuth PECTin-739and / or Omeprazole in the treatment of gastric benign ulcer（GU）.[ Methods ] A total of 278consecutive outpatients with GU were randomly divided into the following groups ： group A treated with Kangfuxin Liquid,group B treated with Kangfuxin Liquid combined with Colloidal Bismuth PEC Tin739,group C treated with Kangfuxin Liquid combined with Omeprazole,and group D treated with Kangfuxin Liquid combined with Colloidal Bismuth PECTin-739and Omeprazole.Four weeks after treatment,the patients ’ symptoms such as bellyache,epigastric distension,nausea,vomiting,sour regurgitation,heartburn as well as the adverse reactions were observed and recorded.[ Results ] The total effective rates for nausea and vomiting were 50.72%,72.22%,50.74%,and 75.71%.,respectively in group A,B,C,and D after treatment,and the difference between group A and group B,group A and group D,group C and group D was statistically significant（P 0.05）.The total effective rates for bellyache and epigastric distension were 52.17%,68.06%,65.67%,and 95.71% respectively in group A,B,C,and D after treatment.There were significant differences between group A,B,C and group D（P 0.05） The difference between group A and group B or group A and group C was insignificant（P 0.05） The total effective rates for sour regurgitation and heartburn were 53.62%,80.56%,52.24%,and 87.14%,respectively in group A,B,C,and D after treatment.The differences between group A and group B,between group A and group D,and between group C and group D were statistically significant（P 0.05）.[ Conclusion ] Kangfuxin Liquid was effective,suitable for mild GU.Kangfuxin Liquid combined with Colloidal Bismuth PECTin-739has better effect on medium GU.Kangfuxin Liquid combined with Colloidal Bismuth PECTin739and / or Omeprazole is the most effective for GU,especially for severe GU.