ABO新生儿溶血病干预效果分析

Analysis on intervention in abo incompatible hemolytic disease of the newborn

目的探讨ABO新生儿溶血病的干预价值。方法对夫妇ABO血型不合1 341例孕妇进行血清抗体效价监测,对抗体效价>1∶128者进行药物治疗,并监测抗体效价,未接受治疗者作为对照组,比较两组新生儿ABO溶血病发生情况。结果 1 341例孕妇中筛查阳性946例,阳性率70.54%。792例孕妇接受治疗,治疗有效率为78.16%,ABO新生溶血发生率为55.56%,对照组发生率为76.62%,2组间发生率比较差异有统计学意义(χ2=23.64,P<0.01)。结论南宁地区新生ABO溶血病发生率较高,通过孕期IgG抗A(B)效价筛查,对高风险人群进行预防性干预可有效地降低新生ABO溶血病的发生。

Objective： To investigate the clinical significance of intervention in ABO incompatible hemolytic disease of the newborn.Methods： The antibody＇s titer of 1 341 pregnant women with ABO incompatible were detected in serum.The criteria for applying medication was high antibody＇s titer（≥1∶ 128）.Accompanied by dynamic detection of their antibody＇s titer.The cases did not accepted medication as Control group.Results： 946 cases were high antibody＇s titer among 1 341cases（70.54%）.There were 792 cases accepted the treatment,and it took effect on 78.16% cases after the treatment.The rate of hemolytic disease of newborns was 55.56% in intervention group,76.62% in control group,and there was no significance of that between the two groups.Conclusion： The rate of hemolytic disease of newborns was high in Nanning.In order to reduce the rate of hemolytic disease of newborn,the antibody＇s titer should be detected,and the intervention also should be carried out in this area.