一种新型希夫碱钯配合物的晶体结构及抗肿瘤活性研究

Crystal Structure and Antitumor Activity of a New Schiff Base Palladium Complex

以自行合成的一种新型希夫碱——胡椒乙胺缩吡啶-2-甲醛(L)作为有机配体,与PdCl2配位反应合成一种希夫碱-钯(Ⅱ)配合物[PdCl2L](1)。通过红外光谱、元素分析和电喷雾质谱对配合物1进行结构表征,用X射线单晶衍射分析确定其晶体结构。通过MTT法测定了配合物1对5种人肿瘤细胞株的体外抗肿瘤活性,结果显示配合物1对人乳腺癌细胞MDA-MB-231有较好的增殖抑制活性,其IC50为(6.98±1.43)μmol/L,对其他4种肿瘤株的抑制活性则较低,表明配合物1对于不同肿瘤细胞表现一定的毒性选择性,表现出潜在的抗肿瘤药用前景。

A new Schiff base 3,4-methylenedioxy-phenethylamine-pyridine-2-formaldehyde（L）,was synthesized as ligand.The reaction of L with PdCl2 afforded the first palladium（Ⅱ） complex of L（complex 1）.Complex 1 was characterized by IR,elemental analysis,ESI-MS,and structurally determined by X-ray single crystal diffraction analysis.In vitro cytotoxicity test against six human tumor cell lines by MTT method showed that complex 1 exhibited significant cytotoxicity against the MDA-MB-231 tumor cell,with IC50 value of（6.98±1.43） μmol/L,while low cytotoxicity to the other five tumor cell lines（including A549,HeLa,NCI-H460,MGC80-3 and BEL7404）,which indicated that complex 1 showed some cytotoxic selectivity on these tested tumor cell lines,suggesting its potential for the antitumoral applications.