期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

阿尔茨海默病治疗的研究进展 被引量：1

Research progress of treatment of Alzheimer＇s disease
原文传递
导出
摘要 阿尔茨海默病（AD）是一种隐匿性起病，进行性恶化的神经退行性疾病，临床最初表现为认知功能障碍，并有可能在5～10年内完全衰退。患者往往伴随严重的记忆力丧失、精神行为异常、人格改变、言语功能障碍，无法独立生活，最终近乎于植物状态。Ferri等采用DISMOD软件在全球60岁以上人群中估计，全球的痴呆患者人数到2040年将达到8llO万左右。
作者 朱逸溪
机构地区 上海养志康复医院
出处 《神经疾病与精神卫生》 2013年第3期317-321,共5页 Journal of Neuroscience and Mental Health
关键词 阿尔茨海默病 淀粉样蛋白 TAU蛋白 线粒体治疗 NMDA受体拮抗剂 促黄 体激素 胰高血糖素样肽物 RNAI技术 Alzheimer＇s disease Amyloid tau protein Mitochondrial therapy NMDAantagonists Luteinizing hormone GLP-1 RNAi technology
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献39

  • 1Ferri CP,Prince M,Brayne C,et al.Global prevalence of de-mentia:a Delphi consensus study [J].Lancet,2005,366(9 503):2 112-2 117.
  • 2Smith MA,Zhu,X,Tabaton M,et al.Increased iron and freeradical generation in preclinical Alzheimer disease and mildcognitive impairment [J].J Alzheimers Dis,2012,19(1):363-372.
  • 3Schellenberg GD,Montine TJ.The genetics and neuropathol-ogy of Alzheimer,s diease [ J].Acta Neuropathol,2012,124.3):305-323.
  • 4Ansari MA,Scheff SW.Oxidative stress in the progression ofAlzheimer disease in the frontal cortex[J].J Neuropathol ExpNeurol,2010,69(2):155-167.
  • 5Corrada MM,Kawas CH,Hallfrisch J,et al.Reduced risk ofAlzheimer,s disease with high folate intake:the BaltimoreLongitudinal Study of Aging[J].Alzheimers Dement,2005.1.1):11-18.
  • 6Zandi PP,Anthony JC,Khachaturian AS,et al.Reduced riskof Alzheimer disease in users of antioxidant vitamin supple-ments:the Cache County Study[J].Arch Neurol,2004,61(1):82-88.
  • 7Lass A,Forster MJ,Sohal RS.Effects of coenzyme Q10 andalpha-tocopherol administration on their tissue levels in themouse:elevation of mitochondrial alpha-tocopherol by coen-zyme Q10[J].Free Radic Biol Med,1999,26( 11/12):1 375-1 382.
  • 8Murphy MP,Smith RA.Targeting antioxidants to mitochon-dria by conjugation to lipophilic cations [J].Annu Rev Phar-macol Toxicol,2007,47:629-656.
  • 9Siedlak SL,Casadesus G.Webber KM,et al.Chronic antioxi-dant therapy reduces oxidative stress in a mouse model ofAlzheimer's disease[J].Free Radic Res,2009,43 ( 2):156 -164.
  • 10Aliev G,Liu J,Shenk JC,et al.Neuronal mitochondrial a-melioration by feeding acetyl-L-carnitine and lipoic acid toaged rats[J].J Cell Mol Med,2009,13(2):320-333.

同被引文献31

  • 1Gong CX, Grundke -Iqbal I, Iqbal K. Targeting Tau proteinin Alzheimer's disease[J], Drugs Aging, 2010,27 (5) : 351 -365.
  • 2Reitz C, Mayeux R. Alzheimer disease: epidemiology, diag-nostic criteria, risk factors and biomarkers[J]. Biochem Phar-macol,2014,88(4) :640?651.
  • 3Jacob Newman Marcus, Joel Schachter. Targeting Post -translational Modi? cations on Tau as a Therapeutic Strategyfor Alzheimer’ s Disease [J]. J Neurogenetics, 2011, 25 ( 4 ):127-133.
  • 4Adams SJ.Crook RJ, Deture M,et al. Overexpression of wild-type murine tau results in progressive tauopathy and neuro-degeneration[J]. Am J Pathol,2009,175(4) :1 598 - 1 609.
  • 5Mocanu M,Nissen AE, Mandelkow EM. The potential for be-ta-structure in the repeat domain of Tau protein determinesaggregation,synaptic decay, neuronal loss,and coassemblywith endogenous Tau in inducible mouse models of Tauopathy[J]. J Neurosci,2008,28(3) :737-748.
  • 6Buee L, Bussiere T,Buee- Scherrer V, et al. Tau proteinisoforms, phosphorylation and role in neurodegenerative disor-ders [J]. Brain Res Rev,2000,33(1) :95 -130.
  • 7Martin L, Latypova X, Terro F. Post-translational modifica-tions of Tau protein: Implications for Alzheimer,s[J]. Neuro-chem Int,2011,58(4):458 - 471.
  • 8Cardenas-Aguayo Mdel C, G6mez-Virgilio L, DeRosa S, etal. The role of tau oligomers in the onset of Alzheimer’s dis-ease neuropathology [J]. ACS Chem Neurosci* 2014, 5 (12):1178-1 191.
  • 9Jayapalan S. Natarajan J. The role of CDK5 and GSK3B kina-ses in hyperphosphorylation of microtubule associated proteintau (MAPT) in Alzheimer's disease[J], Bioinformation,2013,9(20):1 023-1 030.
  • 10Martin L, Page G, Terro F. Tau phosphorylation and neuro-nal apoptosis induced by the blockade of PP2A preferentiallyinvolve GSK3p[J]. Neurochem Int,2011,59(2) : 235 - 250.

引证文献1

二级引证文献1

神经疾病与精神卫生
2013年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部