神经症患者的心理健康与超敏C反应蛋白的关系

Relationship between Psychological Status and Hypersensitive C-reactive Protein in Neurosis Patients

目的探讨神经症患者的心理健康状况与超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)水平之间的关系。方法采用90项症状自评量表(Symptom Checklist 90,SCL-90)对52例神经症、55例健康被试者进行调查,同时测定其血清hs-CRP。结果神经症患者出现的躯体症状较多,主要表现为失眠、头昏、头痛、胃肠道不适、四肢乏力、心慌、胸闷等症状。神经症患者各因子分均高于健康对照组(P<0.05),且主要集中在焦虑、抑郁、躯体化、人际关系敏感、敌对等因子上。神经症组hs-CRP浓度高于健康对照组(P<0.05)。神经症组SCL-90各因子分值与hs-CRP指标呈明显正相关(P<0.05)。结论神经症患者有较多的躯体化症状,存在明显的心理问题,hs-CRP改变可能与其心理健康水平存在一定的相关性。

Objective To investigate the relationship between psychological health status and the level of hypersen- sitive C-reactive protein （hs-CRP） in patients with neurosis. Methods Fifty-two neurosis patients and 55 healthy adults were assessed by Symptom Checklist 90 （SCL-90）. Their blood samples were collected to test the levels of hs-CRP. Results Neurosis patients had a lot of somatic symptoms, mainly insomnia, dizziness, headache, gastrointestinal discom- fort, limb weakness, palpitation and chest tightness. The SCL-90 scores in neurosis patients were significantly higher than those in the control group （P〈0. 05）, especially obvious in anxiety, depression, somatization, interpersonal sensi- tivity and hostility factors. The hs-CRP level in neurosis patients was significantly higher than that in the control group （P〈0.05）. All SCL-90 factors in neurosis patients had significantly positive correlation with hs-CRP level （P〈0. 05）. Conclusion Neurosis patients have more somatic symptoms and many psychological problems. There is obvious correla- tion between their psychological health status and hs-CRP levels.