同型半胱氨酸、血尿酸与冠心病临床分析

homocysteine, uric acid,in coronary heart disease

目的探讨冠心病患者血中同型半胱氨酸(Hcy)和血尿酸(UA)的含量及它们与冠心病的相关性。方法选取冠心病患者100例作为观察组,其中急性心肌梗死(AMI)组患者50例,不稳定型心绞痛(USAP)组患者50例。稳定型心绞痛(SAP)组患者30例,20例健康者作为对照组,采用利用酶联免疫吸附法(ELISA)测定研究对象Hcy的浓度,用全自动生化分析仪测定UA浓度。结果血中Hcy和UA水平ACS组、SAP组显著高于对照组(P<0.05),ACS组显著高于SAP组(P<0.05),AMI组显著高于USAP组(P<0.05),且Hcy及UA呈正相关。结论冠心病患者血中Hcy、UA浓度与冠心病危险程度存在明显的相关性,可以作为判断冠脉病变严重程度的重要指标。

Objective To detect the levels of plasma serum levels of homocysteine（Hcy）,uric acid（UA） and the correlation of the patients with coronary heart disease（CHD）.Methods 100 patients with CHD were divided into acute myocardial infarction（AMI） group（n=50）,USAP group（n=50）,stable angina pectoris（SAP） group（n=30）,and healthy control group（n=20） subjects matched for age,gender.The levels of plasma Hcy were measured with enzyme-linked immunosorbent assay（ELISA）.UA were measured with uricase colorimetric assay.ResultsThe levels of Hcy,UA in patients with CHD were significantly higher than those in control group（P0.05）.The levels of Hcy,UA in ACS group were significantly higher than those in SAP group（P0.05）.There was significant difference between the AMI and USAP groups（P0.05）.The correlation between Hcy and UA level was positive in CHD.Conclusion There is a significant correlation between Hcy,UA and the risk level of coronary heart disease.These two indexs can evaluate the severity dergee.