常温下2-氨基-6-硫代-6H-噻喃酮-3-腈的合成

The synthesis of 2-amino-6-thio-6 H-thiapyrones-3-nitrile at room temperature

以苯基亚乙烯基丙二腈、CS2为起始原料,DMF为溶剂,碱性较弱的微量NaOH粉末作催化剂,常温下搅拌可以得到较高产率的硫代噻喃酮衍生物.该种方法能高效快捷地构建噻喃酮骨架,避免了强碱乙醇钠的使用,反应条件温和,底物范围良好,后处理方便.

A series of 2-amino-6-thio-6H-thiapyrones-3-nitriles have been synthesized through the domino reactions between 2-（1-arylethylidene）malononitriles and carbon disulfide in DMF, using sodium hydroxide as a base catalyst. These reactions can generate high yields of thio-thiapyrones derivatives at room temperature. This article developed a highly efficient and fast method to build thiapyrones skeleton. It has the advantages of mild reaction condition, good range of substrates, avoiding the use of strong alkali sodium ethoxide, and convenience of the post-processing.