小儿全身性癫痫与髓鞘碱性蛋白关系的研究

Study of myelin basic protein associated with pediatric systematic epilepsy

目的 通过检测脑脊液 (CSF)和血清髓鞘碱性蛋白 (MBP)的含量 ,了解小儿全身性癫痫是否引致髓鞘和血脑屏障(BBB)的破坏。 方法 采用简易MBPELISA法对 47例小儿全身性癫痫病患儿脑脊液和血清标本作MBP定量测定。 结果 在一个月内有全身性癫痫发作的患儿其CSF和血清MBP含量均值明显高于正常对照组 (P <0 0 1)。 结论 小儿全身性癫痫发作可导致CSF和血清MBP升高 ,提示大脑器质性损伤和BBB的破坏。MBP含量的检测可作为全身性癫痫预后评估的一项生化指标。

Objective To investigate the quantitative myelin basic protein (MBP) in cerebrospinal fluid (CSF) and serum in pediatric systematic epilesy (SEP),study the relation between SEP and MBP,and the possibility predicating the injury of myelin and blood brain barrier (BBB) from pediatric SEP.Methods 42 cases were studied during one month after the SEP attack,whose MBP in both CSF and serum were quantitatively tested by easy MBP ELISA method;the quantitative MBP in CSF and serum of 30 control cases were tested too.Results MBP values in CSF and serum of SEP pediatric patients were (2\^95±0\^61)ng/ml and (3\^17±0\^53)ng/ml;whereas(1\^41±0\^19)ng/ml and (1\^30±0\^04)ng/ml in control group.Both mean values of MBP in CSF and serum in studying group were significantly higher than those in control group (either P<0 01).Conclusion There were increasing values of MBP in CSF and serum in pediatric SEP,indicating a demyelinatting pathological course and injury of blood brain barrier.The quantitative test for MBP in CSF and serum should be a reflecting biochemical index of CNS injury associated with SEP,and a prediction for its prognosis.