系统性红斑狼疮患者血清生长激素和泌乳素动态变化的研究

Study on Dynamic Changes of Serum Growth Hormone and Prolactin in Patients with Systemic Lupus Erythematosus

目的 探讨 SLE患者生长激素和泌乳素对促甲状腺激素释放激素反应。方法 用双抗体 RIA法测定促甲状腺激素释放激素注射前及注射后 15、 30、 60、 120 min SLE患者和正常人对照组的血清生长激素和泌乳素。结果 SLE活动期患者注射前和注射后 15、 30、 60、 120 min血清泌乳素水平以及在 60、 120 min时血清生长激素水平显著高于 SLE静止期及正常人对照组 (P0.05)； SLE活动期促甲状腺激素释放激素兴奋试验反应升高的发生率显著高于静止期

Objective To study the response of growth hormone(GH) and prolactin(PRL) to thyrotropin-releasing hormone(TRH) in patients with systemic lupus erythematosus (SLE). Methods The levels of PRL and GH level were measured by radioimmunoassay in sera from 34 patients with active SLE,13 patients of inactive SLE and 10 matched controls. Results There was a significant difference of serum levels of PRL between active group and inactive group as well as controls at 0 min and at 15 min ,30 min, 60 min,120 min after TRH injection. The serum GH levels at 60 min and 120 min were significantly higher in active group than those of inactive group and controls. The proportions of patients with increased response to TRH were signifiat higher in active group than those of inactive group. The abnormal response to TRH in active SLE was related to the disease activity of the patients. Conclusion The increasing levels of serum GH and PRL is likely to be associated with the pathogenesis of SLE.