葛根素注射液及注射用葛根素体外溶血对比研究

Comparative study of in-vitro hemolysis of puerarin injection and puerarin for injection

目的考察两种不同剂型的葛根素注射剂体外致家兔红细胞溶血差异性,为临床安全用药提供依据。方法采用改良体外试管法评价葛根素注射液及注射用葛根素对家兔红细胞的溶血作用。结果葛根素终浓度相等时,葛根素注射液致家兔红细胞体外溶血程度显著高于注射用葛根素,葛根素注射剂两种剂型体外均可引起家兔红细胞形态改变。结论不同剂型的葛根素注射剂,其体外溶血存在差异性。

Objective To investigate the difference in in-vitro hemolysis between two different formulations of puerarin injections,and to provide the basis for clinical medication safety.Methods Improved in-vitro hemolysis tests were used to evaluate rabbit erythrocyte hemolytic degree induced by puerarin injection and puerarin for injection.Results Rabbit erythrocyte hemolysis ratio induced by puerarin injection was significantly higher than that induced by puerarin for injection of the same concentration.Both dosage forms of puerarin injections could change rabbit erythrocyte morphology in vitro.Conclusion There is difference between different dosage forms of puerarin injections.