简短精神状态检查与事件相关电位在痴呆诊断中的应用

Application of MMSE and P300 in the diagnosis of dementia

目的 :评价简短精神状态检查 (MMSE)与事件相关电位 (P30 0 )在痴呆诊断中的价值和相关性。方法 :对 35例大脑半球损害的病人同时或短期内进行 MMSE和 P30 0测查。结果 :1MMSE与 P30 0的潜伏期和波幅的一致率分别为 6 3%和 6 9% ,经检验两种方法的结果是相符合的。文化程度影响 MMSE成绩 ,年龄影响 P30 0潜伏期 ,但两者对 P30 0波幅无明显影响。 2 MMSE成绩与 P30 0波幅正相关 ,而与潜伏期无明显相关 ,注意集中与顶潜伏期相关 ,定向与波幅相关。结论 :MMSE和 P30 0在判断认知障碍中有较高的符合率 ,但分析结果时要考虑文化和年龄的影响。 P30 0波幅与 MMSE得分之间的相关性比潜伏期与 MMSE成绩之间更明显 ,提示 P30

Objective:To estimate the appliancation value and correlation of MMSE and P300 in the study of dementia. Methods:35 patients with cerebral hemisphere damage were examined by MMSE and P300 simultaneously or within short time.Results:①The consistent rate is 63% and 69% respectively between MMSE and P300 latent period, and between MMSE and P300 amplitude. The results of two examining methods are accordant with Chi square test. MMSE is under the influence of education degree ,while P300 latent period is evidently influenced by age. ②There is significant correlation between MMSE score and P300 amplitude,but correlationship doesn't exist between MMSE score and P300 latent period. There is correlation between attentive ability and parietal P300 latent period, and between oriented ability and P300 amplitude.Conclusion:Results of MMSE accord with those of P300 in diagnosing dementia,but influence of education degree and age on MMSE and P300 should be considered. The patients with lower scores of MMSE might have decreased P300 amplitude. It is suggested that P300 amplitude is a significant and constant parameter. [FK(WB80011。6]