EZH2蛋白在乳腺癌中的表达及其临床意义

THE EXPRESSION AND CLINIC SIGNIFICANCE OF EZH2 PROTEIN IN BREAST CANCER

目的研究EZH2蛋白在乳腺癌中的表达情况及其临床意义。方法通过免疫组化SP法检测EZH2蛋白在40例乳腺癌伴有淋巴结转移、63例乳腺癌不伴淋巴结转移及31例乳腺增生组织中的表达情况。结果从乳腺增生-乳腺癌不伴淋巴结转移-乳腺癌伴有淋巴结转移,EZH2蛋白阳性表达率依次增强,分别为22.58%、52.38%、75.00%。EZH2与患者乳腺癌及淋巴结转移呈显著关系(p<0.01)。结论 EZH2蛋白在乳腺癌中高表达,尤其是在乳腺癌伴有淋巴结转移中的表达显著提高,提示EZH2的过表达与乳腺癌进展及不良预后有关。

Objective This study is to explore the expression and clinic significance of EZH2 （enhancer of zeste homolog2） protein in breast cancer. Methods The expressions of EZH2 protein in 40breast cancer with lymph node metasta- sis tissues, 63breast cancer without lymph node metastasis tissues,31 hyperplasia of mammary glands tissues by SP immunohis- toehemical method. Results The rate of expressions of EZI-I2 protein in 40breast cancer with lymph node metastasis tissues, 63breast cancer without lymph node metastasis tissues,31 hyperplasia of mammary glands tissues were 75.00% （30/40） ,52. 38% （33/63） ,22.58% （7/31）respectively. The expressions of EZH2 protein in cancer tissions was higher than that in hy- perplasia of mammary glands tissues（p 〈0. 01 ）. Conclusion The abnormal expressions of EZH2 are closely associated with the development of breast cancer,which may play an important role in the development of breast cancer. The overexpressions of EZH2 is correlated to breast cancer progression and poor prognosis.