阿尔茨海默病与血管性痴呆伴发抑郁的相关研究

Study on the difference of depression in alzheimer's disease and depression in vascular dementia

目的探讨阿尔茨海默病与血管性痴呆患者伴发抑郁的不同临床特征。方法评估106例阿尔茨海默病与83例血管性痴呆患者,均经量表测评区分为轻、中和重度痴呆;并分别进行抑郁量表测查,观察不同抑郁症状。结果血管性痴呆组重症抑郁症患病率显著高于阿尔茨海默病组(P<0.05);两组间轻型抑郁症的患病率并无明显差异(P>0.05);血管性痴呆组患者抑郁症状数显著高于阿尔茨海默病组(P<0.05);且"经常感到精力减退或疲乏"及"反复出现想死的念头,或有自杀、自伤行为"的出现频率在血管性痴呆组较阿尔茨海默病组显著增高(P<0.05)。结论血管性痴呆患者较阿尔茨海默病患者更易伴发重症抑郁症;易出现精神运动性症状如精力减退等。

Objective To analyze and compare the clinical characteristics of depression in Alzheimer＇s disease（AD） and vascular dementia（VaD）.Methods One hundred and six AD patients and eighty three VaD patients were included into this study and assessed the depression condition.Results Major depressive disorder（MDD） was more prevalent in VaD patients than in AD patients（P 0.05）.Psychomotor symptoms,such as feeling loss of energy and tired all the time,were more prevalent in VaD patients than in AD patients（P 0.05）.Conclusion VaD patients are prone to suffer from MDD.However,VaD patients are more likely to leading to psychomotor symptoms.