B型钠尿肽和大内皮素1对心力衰竭患者的预后作用及其与心血管病关系的研究

The study on prognostic value of BNP and ET-1 in severe heart failure and the relationship whit cardiovascular disease

目的研究B型钠尿肽(BNP)和内皮素1(EP-1)对心力衰竭患者的预后作用及其与心血管病关系。方法选择就诊的心力衰竭患者作为观察组,健康者作为对照组,采用酶联免疫分析法(ELISA)的方法检测外周血中BNP、EP-1的水平。结果心力衰竭患者外周血中BNP和EP-1明显高于健康者,并且心力衰竭的分期越高、病情越严重,患者外周血中BNP和EP-1的含量也越高;心力衰竭合并心房颤动的患者BNP和EP-1含量明显高于未合并房颤的患者,合并心肌梗死的患者BNP和EP-1含量也明显高于未合并心肌梗死的患者。结论 BNP和EP-1对心力衰竭的早期诊断、合并房颤和心梗的判断、预后的分析均有积极意义。

Objective Study the prognostic value of BNP and ET-1 in patients and its relationship with cardiovascular disease.Methods Choose patients with heart failure as the observation group and healthy people as control group,use method for the detection of BNP,EP 1 levels in peripheral blood.Results BNP and ET-1 levels in heart failure patients are significantly higher than that in healthy persons,and BNP and ET-1 levels in heart failure patients with more serious condition are also higher;BNP and ET-1 levels in patients with heart failure complicated with atrial fibrillation are significantly higher than that without atrial fibrillation patients,associated BNP and EP-1 levels in patients with myocardial infarction was significantly higher than that in patients without myocardial infarction.Conclusion BNP and ET-1 play a positive role in early diagnosis of heart failure,analysis atrial fibrillation and myocardial infarction,prognosis judgement.