鼻咽癌放疗后鼻窦炎的临床干预方法及效果

The clinical interventions and experience of sinusitis after radiotherapy for nasopharyngeal carcinoma

目的探讨鼻咽癌放疗后鼻窦炎的临床干预方法及效果。方法选取就诊的120例鼻咽癌患者作为研究对象,其中有60例鼻咽癌患者在放射治疗初期就接受干预治疗作为观察组,60例鼻咽癌患者在接受放射治疗时未进行临床干预作为对照组。比较两组患者3个月、6个月及12个月鼻窦炎患病率。结果观察组患者3个月、6个月及12个月鼻窦炎的患病率分别为12.33%、31.67%和11.67%,对照组患者3个月、6个月及12个月鼻窦炎的患病率分别为35.00%、73.33%和12.33%,经统计学分析,观察组患者的3个月和6个月鼻窦炎患病率明显低于对照组,差异有显著性(P<0.05)。结论鼻咽癌放射治疗后鼻窦炎的发病高峰为3个月至1年,在治疗初期即开始进行临床干预有利于降低鼻咽癌放射治疗后鼻窦炎的患病率。

Objective To study the clinical interventions and experience of sinusitis after radiotherapy for nasopharyngeal carcinoma. Methods A total 120 patients with nasopharyngeal carcinoma were enrolled into this study in our hospital between Jan 2005 and Jan 2012. 60 pa- tients with nasopharyngeal carcinoma who received clinical interventions were enrolled into this study as observation group, and 60 patients with na- sopharyngeal carcinoma who did not receive clinical interventions were enrolled into this study as control group. The 3 - month, 6 - month and 12 - month incidence rates of sinusitis in the two group were compared and analyzed. Results The 3 - month, 6 - month and 12 - month incidence rate of the observation group was 12.33% ,31.67% and 11.67%, respectively. The 3 - month, 6 - month and 12 - month incidence rate of the control group was 35.00%, 73.33% and 12.33%, respectively. The 3 - month, 6 - month incidence rate of the observation group was signifi- cantly lower than that of the control group. Conclusion The pathogenic peak age of sinusitis after radiotherapy for nasopharyngeal carcinoma was from 3 months to 12 months. Nasopharyngeal carcinoma patients should receive clinical interventions as soon as possible in order to reduce the inci- dence rate of sinusitis after radiotherapy for nasopharyngeal carcinoma.