阴沟肠杆菌169株的临床分布及耐药性分析

Analysis of the distribution features and drug resistance of 169 isolates of Enterobacter cloacae

目的通过回顾性分析阴沟肠杆菌感染的临床分布及药敏结果,为临床合理用药提供指导。方法对近2年临床分离出的169株阴沟肠杆菌进行感染标本来源、临床分布及药敏结果等的总结分析。结果 2011年6月至2013年4月共分离出169株阴沟肠杆菌,菌株来源主要为痰液(57.4%)和血液(11.8%);菌株分布于多个病区;阴沟肠杆菌对碳青霉烯类、头孢吡肟、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦钠及左氧氟沙星的敏感性较高。结论临床阴沟肠杆菌主要引起呼吸道及血行感染;阴沟肠杆菌对三代头孢菌素耐药性较严重,表现为多药耐药趋势,碳青霉烯类及含β-内酰胺酶抑制剂类抗生素仍为治疗阴沟肠杆菌感染的首选用药。

Objective To analyze the distribution of Enterobacter cloacae （ E. cloacae） infection and drug sensitivity of E. cloacae iso- lates obtained from our hospital for guiding the rational use of antibiotics. Methods Retrospective analysis of the distribution of 169 E. cloacae i- solates isolated from our hospital from June 2011 to April 2013 and drug resistance of these isolates was made. Results Totally 169 E. cloacae isolateds were obtained. The percentages of these isolates obtained from sputum and blood were 57.4% and 11.8%, respectively. The isolates distributed in many wards, and most of them were sensitive to carbapenems, cefepime, piperacillin/tazobactam, cefoperazone/sulbactam, and levofloxacin. Conclusion E. cloacae mainly causes respiratory and bloodstream infections in our hospial. It is muhidrug resistant especially for the third generation cephalosporins. Carbapenems and antibiotics containing 13 - lactamase inhibitors remain to be the first choice to treat the severe infection caused by E. cloacae.