维拉帕米对创伤后大鼠痛觉过敏的影响

Antinociceptive effects of verapamil on hyperalgesia of rats after trauma

目的 观察维拉帕米对创伤后痛觉过敏的影响。方法 Wistar大鼠 4 8只 ,以截肢作为创伤模型。大鼠创伤后分别腹腔注射不同剂量的维拉帕米、芬太尼、芬太尼 +维拉帕米以及生理盐水 ,于创伤后15、30、60、12 0min观察创伤部位周围皮肤痛阈变化情况。结果 10mg kg维拉帕米即可抑制创伤部位周围皮肤的痛阈下降 ,其中芬太尼 +维拉帕米作用最强。结论 维拉帕米可抑制痛觉过敏 ,具有一定的镇痛作用并加强芬太尼的镇痛效应。

Objective To investigate the antinociceptive effect of verapamil on hyperalgesia of rats after trauma. Methods Rat trauma model was established in 48 Wistar rats by limb amputation. The animals were intraperitoneally injected with verapamil (5 mg/kg, 10 mg/kg or 20 mg/kg), Fentanyl (15 μg/kg), the combination of the former (10 mg/kg) and the later (15 μg/kg) and normal saline respectively and the pain threshold around the wounded site was recorded at the 15, 30, 60 and 120 min after the amputation. Results Verapamil of the dosage of 10 mg/kg could induce the pain threshold and the combination of the 2 drugs exerted most powerful effects on the pain threshold. Conclusion Verapamil contributes to the antinociceptive and intensifies the effect of Fentanyl because of its potency of inhibiting hyperalgesia after trauma.