慢性阻塞性肺疾病急性加重期C反应蛋白的研究分析

Research of changes of C-reactive protein in acute aggravating period in patients with chronic obstructive pulmonary disease

目的 分析慢性阻塞性肺疾病急性加重期（AECOPD）C反应蛋白（CRp）的变化,并探讨其临床意义.方法 对68例AECOPD患者CRP水平和白细胞计数（WBC）的测定,同时测定肺功能和血气指标.结果 治疗后第5天、7天CRP水平、肺功能和血气分析指标均较治疗前显著改善,差异有统计学意义（P＜0.05）.结论 CRP水平在慢性阻塞性肺疾病急性加重期明显升高,且病情越重、肺功能损害越重以及血气分析测定呼吸衰竭越严重,升高的程度越明显,与病情的严重程度呈正相关.

Objective To investigate the changes of C-reactive protein（CRP） in acute exacerbation of chroric obstructive pulmonary disease （AECOPD）,and to explore its clinical significance.Methods The CRP level,white blood cell count（WBC）,lung function and gas index of 68 patients with AECOPD were determined before treatment and after treatment.Results After treatment for 5 days and 7 days,the CRP level,lung function and gas indexwere significantly improved （P ＜0.05）.Conclusion CRP level increased significantly in AECOPD.The more serious of the sick condition,lung function damage and respiratory failure,the higher level of the CRP.CRP level has positive correlation with the severity of the disease.