摘要
目的 探讨宫颈上皮内瘤样变(CIN)伴人乳头瘤病毒(HR-HPV)采用高频电波刀行宫颈环形电切术(LEEP)治疗效果.方法 选择收治80例宫颈上皮内瘤变伴HPV感染患者行LEEP手术治疗并分别检测手术前及术后3个月HR-HPV DNA负荷量,同时行阴道检查及宫颈定点活检.结果 LEEP手术前不同级别CIN的HPV荷量之间差异不显著(F=0.45,P>0.05);术后3个月CIN Ⅰ级19(86.4%)转为慢性炎症、CINⅡ级36(83.7%)例转为慢性炎症;CINⅢ级13(86.6%)例转慢性炎症,宫颈HPV负荷量术后转阴率为85%且HPV负荷量低的患者较负荷量高的患者术后转阴的概率更高.结论 LEEP刀在治疗宫颈上皮内瘤变中效果显著,同时可有效降低宫颈HPV负荷量,值得临床大力推广应用.
Objective To explore the curative effect of loop electrosurgical excision procedure (LEEP) on cervical intra-epithelial neoplasia(CIN) infected with high risk human papilloma virus (HR-HPV).Methods 80 CIN patients with HPV infection underwent LEEP were selected.HR-HPV DNA load was detected before operation and 3 months after operation,and at the same time,vaginal examination and cervical directed biopsy were conducted.Results Before LEEP operation,the differences between different levels of CIN HPV load were not significant(P >0.05,F =0.45).3 months after operation,CIN Ⅰ grade 19 cases (86.4%) turned to chronic inflammation,CIN Ⅱgrade 36 cases (83.7%) turned to chronic inflammation,CINⅢ grade 13 patients (86.6%) were chronic inflammation.Cervical HPV load postoperatively negative rate was 85% and the lower HPV load,the higher postoperatively negative rate.Conclusion LEEP is the effective treatment for cervical lesion and can significantly decrease the HPV-DNA loading at cervix.
出处
《中国基层医药》
CAS
2013年第16期2462-2464,共3页
Chinese Journal of Primary Medicine and Pharmacy