复发性口腔溃疡口腔微生态探索

Analysis of the oral microecology in recurrent oral ulcer

目的 研究和探索复发性口腔溃疡患者口腔微生态菌群情况,分析口腔微生态与复发性口腔溃疡的相关性.方法 收集20例复发性口腔溃疡患者唾液,21例复发性口腔溃疡愈合患者唾液,20例健康志愿者唾液,以Gb-作为革兰阴性杆菌标记,Gb＋作为革兰阳性杆菌标记,Gc-作为革兰阴性球菌标记,Gc＋作为革兰阳性球菌标标,比较各组口腔菌群构成,并进行定量对比分析.对三组唾液中的奈瑟氏菌、链球菌、韦荣氏菌的含量变化进行分析,研究口腔微生态变化情况.结果 溃疡组韦荣氏菌和链球菌的含量对数值明显低于健康对照组（P＜0.05）；愈合组和溃疡组的奈瑟氏菌和韦荣氏菌含量具有显著差异（P＜0.05）；愈合组链球菌对数值明显低于健康对照组（P＜0.05）.结论 复发性口腔溃疡与口腔微生态具有相关性,韦荣氏菌含量情况与复发性口腔溃疡发病关系密切,可能具有维持口腔环境稳定的作用.

Objective To explore flora of patients with recurrent oral ulcer,to analyze the relationship between oral microecology and recurrent oral ulcer.Methods The saliva of 20 patients with recurrent oral ulcer,21 patients with recurrent oral ulcer healing,20 healthy volunteers were collected.Gb marked as gram-negative bacilli,Gb＋marked as gram-positive bacteria,Gc marked as gram-negative cocci,Gc＋ as standard standard of Gram-positive cocci.The oral flora was quantitatively analyzed.Neisseria,Streptococcus,Wei Rongshi bacteria content in the saliva were analyzed in the three groups.The oral microecology changes was studied.Results Wei Rong bacteria and streptococci content value in the ulcer group were significantly lower than the healthy control group （P ＜ 0.05）.Neisseria and Wei Rong bacteria content between healing group and ulcer group had significant differences （P ＜ 0.05）.A streptococci value of the healing group was significantly lower than the healthy control group（P ＜ 0.05）.Conclusion Recurrent oral ulcer has correlation with oral microecology,Wei Rongshi bacteria content is closely related with the incidence of recurrent oral ulcer and may maintain the stable of oral environment.