复发性阿弗他溃疡患者外周血中IL-2和IL-10水平变化及临床意义

Alteration of IL-2 and IL-10 in patients with recurrent aphthous ulcer and its clinical significance

目的探讨复发性阿弗他溃疡(RAU)患者外周血白介素(IL)-2、IL-10水平变化及临床意义。方法酶联免疫吸附试验测定40例RAU患者(RAU组)及29例健康对照者(健康对照组)血清中IL-2和IL-10水平。结果RAU组患者血清中IL-2水平显著低于健康对照组(t=-2.638,P<0.05),IL-10水平显著高于健康对照组,差异有统计学意义(t=2.201,P<0.05)。IL-2与IL-10水平呈显著负相关(r=-0.638,P<0.01)。结论 RAU患者血清中IL-2和IL-10水平发生变化,提示细胞因子IL-2、IL-10与RAU发病有一定关系。

Objective To explore the changes of interleukin-2（IL-2） and interleukin-10（IL-10） in the patients with recurrent aphthous ulcer（RAU）.Methods The serum levels of IL-2 and IL-10 were measured in 40 RAU patients and 29 healthy controls by the ELISA method.Results The serum levels of IL-2 in the RAU group were significantly lower than those in the healthy control group（t=-2.638,P0.05）,and the serum levels of IL-10 in the RAU group were significantly higher than those in the healthy control group,showing statistically significant difference（t=2.201,P0.05）.There was significantly negative correlation between serum IL-2 and IL-10（r=-0.638,P0.01）.Conclusion The serum levels of IL-2 and IL-10 in RAU are changed,which suggests that IL-2 and IL-10 are related with the pathogenisis of RAU.