利培酮对急性脑梗死后精神障碍患者神经功能及生活质量的影响

Influence of risperidone on neurological function and quality of life of patients with mental disorder after acute cerebral infarction

目的观察利培酮对急性脑梗死后精神障碍患者神经功能恢复与生活质量的影响。方法将2012年3—12月住院的急性脑梗死患者依据临床表现分为利培酮治疗组(伴精神障碍)62例、随机选择对照组(不伴精神障碍)96例,分别于治疗前、治疗后2周进行神经功能缺损评分量表(NIHSS)及日常生活能力量表(ADL)评定。结果治疗前治疗组NIHSS评分高于对照组,而ADL评分低于对照组,差异均有统计学意义(t=6.050、-12.502,P<0.05),NIHSS评分分别为(14.11±1.76)、(12.30±1.81)分;ADL评分分别为(33.40±4.22)、(42.48±4.60)分;治疗后2周治疗组NIHSS及ADL评分与对照组比较,差异均无统计学意义(t=0.963、-0.779,P>0.05),NIHSS评分分别为(8.81±1.62)、(8.56±1.51)分;ADL评分分别为(67.61±6.67)、(68.50±7.19)分。结论利培酮能有效促进急性脑梗死伴精神障碍患者神经功能恢复及生活质量的改善。

Objective To observe the influence of risperidone on the neurological function and the quality of life in the patients with mental disorder after acute cerebral infarction（ACI）.Methods The inpatients with ACI enrolled in this hospital from March to December 2012 were divided into the risperidone treatment group（n=62,complicating mental disorder）and the control group by the random sampling（n=96,without mental disorder）.The neurological deficit score（NIHSS） and the ability of daily living（ADL） were conducted before treatment and after 2-week treatment.Results The NIHSS score and the ADL scores before treatment in the risperidone treatment group were higher than those in the control group,while the ADL scores in the risperidone treatment group were lower than those in the control group with statistically significant differences（14.11±1.76 vs.12.30±1.81,t= 6.050,P0.05;33.40 ±4.22 vs.42.48 ±4.60,t=-12.502,P 0.01）,and the NIHSS scores and ADL scores ater 2-week treatment had no statistically significant differences beteen the two groups（8.81±1.62 vs.8.56±1.51,t=0.963,P0.05;67.61±6.67 vs.68.50± 7.19,t=-0.779,P 0.05）.Conclusion Risperidone can effectively promote the neural function recovery and the improvement the quality of life in the patients with ACI complicating mental disorders.