Aurora B激酶在软骨肉瘤中的表达及临床意义

Expression and significance of Aurora Kinase B in chondrosarcoma

目的:检测Aurora B激酶在软骨肉瘤中的表达及将其作为软骨肉瘤新的预后指标及分子治疗靶点的可行性。方法:用免疫组织化学SP法,研究软骨肉瘤(69例)和软骨瘤(39例)组织中Aurora B激酶的表达情况,并探讨Aurora B激酶的表达与软骨肉瘤各临床病理特征的关系。结果:Aurora B激酶在软骨肉瘤中的表达明显高于在软骨瘤中的表达,差异有统计学意义(P<0.01);Aurora B激酶在软骨肉瘤普通类型低级别组的表达低于在中、高级别组的表达,差异有统计学意义(P<0.01);AuroraB激酶在软骨肉瘤的复发组与非复发组、转移组与非转移组中的表达,差异也有统计学意义(P<0.05),而与年龄、性别临床参数无统计相关性(P>0.05)。结论:Aurora B激酶可能通过某种机制参与软骨肉瘤的发生、发展过程,研究Aurora B激酶阳性表达可以作为软骨肉瘤预后预测的新指标及软骨肉瘤治疗的分子靶点。

Objective：To test the expression of Aurora Kinase B in chondrosarcoma and to explore the potential of Aurora Kinase B as a new prognosis marker and molecular target against chondrosarcoma.Methods：The expression of Aurora Kinase B in chondrosarcoma（69cases）and chondroma（39cases）was detected by immunohistochemical assay.Results：The positive expression rate of Aurora Kinase B in chondrosarcoma cases was significantly higher than that in chondroma cases（P0.01）.The positive expression rate of Aurora Kinase B in common chondrosarcoma of low class cases was significantly lower than that in middle and high class cases（P0.01）;The expression of Aurora Kinase B in chondrosarcoma cases was quite different between reoccurring cases and non reoccurring cases,it was the same as in metastasis cases and non metastasis cases（P0.05）.However,there was no correlation with other clinicopathologic features.Conclusion：Aurora Kinase B may play a significant part in the process of occurrence,progression as well as metastasis of chondrosarcoma.Then Aurora Kinase B can be considered as a new molecular target against chondrosarcoma.