血清BNP水平在肺源性和心源性呼吸困难鉴别诊断的相关性分析

Correlation between serum brain natriuretic peptide level and differential diagnosis of pulmonary and cardiogenic breathing difficulty

目的:探讨血清BNP水平在肺源性和心源性呼吸困难鉴别诊断的相关性。方法:选取例因心衰导致肺源性以及心源性呼吸困难的患者,根据心衰类型将其分为左心衰组(47例)和右心衰组(76例)。另选取40例健康者作为对照组。采用全自动免疫分析仪按NYHA分级测量参与者的血清BNP水平,分析血清BNP水平与左右心衰的相关性。结果:心源性与肺源性心衰差异具有统计学意义(P<0.05)。与对照组相比,右心衰组和左心衰组均明显高于对照组,其血清BNP水平与左右心衰程度均呈正相关(R=0.985、0.795,P<0.05)。结论:血清BNP水平与左右心衰呈正相关,血清BNP可作为鉴别呼吸困难病因以及左右心衰的客观指标,对实施救治方案有重要临床意义。

Objective：To observe relation between change of serum brain natriuretic peptide（BNP）level and differential diagnosis of pulmonary and cardiogenic breathing difficulty.Methods：A total of 123patients with pulmonary and cardiogenic heart failure were divided into left heart failure group（47 cases）and right heart failure group（76cases）according to types of heart failure.Forty healthy subjects were selected as control group.group.Serum BNP concentration was detected by automatic immunity analyzer,and the relationship between serum BNP level and heart failure was analyzed.Results：Significant difference existed between cardiac and pulmonary（P0.05）.Compared with healthy controls,serum BNP significantly increased in patients with right and left heart failure group（P0.05）,and the elevated levels were positively correlated with the degree of heart failure（r=0.985,0.795,P0.05）.Conclusion：Left and right heart failure and serum BNP levels are positively correlated.Serum BNP level might be a effective clinical serum markers in evaluation of heart failure and etiology of dyspnea.It has important clinical significance in treatment.