原发性口腔典型类癌临床病理分析

Clinicopathology analysis of typical primary oral carcinoid

目的:探讨原发性口腔典型类癌的临床病理特征、组织来源及其诊断和鉴别诊断。方法:对1例口腔典型类癌进行组织病理学观察和免疫组化检测,复习临床资料和相关文献。结果:患者临床表现为右下颌磨牙后区无痛性、渐进性增大包块5年。镜下见肿物主要由中等大小的较一致的上皮样细胞构成,呈巢团状、小梁状或条索状排列,细胞胞浆嗜伊红或透明,核圆居中,染色质均匀分布,核仁不明显,未见核分裂象和坏死,可见大量的鳞状分化。免疫表型:肿瘤细胞CKAE1/AE3、CK7、P63、NSE、和Syn阳性,TTF-1、CD56、和CK20阴性。结论:口腔典型类癌是一种极为罕见的低度恶性肿瘤,临床表现无特异性,其诊断主要依靠组织病理形态和免疫表型,同时必须结合病史、全身检查及随访资料,以排除转移性类癌。

Objective：To explore the clinicopathologic characteristics,origin,diagnosis and differential diagnosis of typical primary oral carcinoid.Methods：The histopathological character and immunophenotype of oral typical carcinoid was studied and clinical data were reviewed as well as other literature.Results：The patient presented with progressive increased painless mass in right mandibular retromolar area for 5years.Microscopic result showed that the tumor was consisted of uniformity epithelioid cells with regular round nuclei,inapparent nucleoli,absence of mitoses,arranging as nests and trabelulae,with many squamous differentiation.Immunophenotype：the tumor cell was positive for CKAE1/AE3,CK7,P63,NSE,Syn,but negtive for TTF-1,CD56,CK20.Conconlusion：oOal typical carcinoid,was of a very rarely low potential malignancy,non-special for clinical manifestation.The diagnosis depends on histopathologic analysis and immunophenotype to exclude metastatic carcinoid.