GRIM-19的表达与膀胱癌组织临床特征的相关性研究

Correlation of GRIM-19 expression and clinical features of bladder cancer

目的:探讨细胞GRIM-19在膀胱癌组织中的表达及与病理分级和临床分期之间的关系。方法:采用Westernblot方法分别检测50例膀胱癌患者膀胱癌组织、癌旁组织及38例正常膀胱组织中GRIM-19的表达情况,进行分析上述指标与膀胱癌病理分级和临床分期的关系。结果:显示GRIM-19膀胱癌、癌旁组织中的表达与正常膀胱组织比较,差异有统计学意义(P<0.01),膀胱癌、癌旁组织中的表达比较,差异具有统计学意义(P<0.05)。膀胱癌、癌旁组织中的表达:临床分级,Ⅰ级逐渐向Ⅲ级下降,差异具有统计学意义(P<0.01);临床分期,T2～T4高于Tis～T1,差异具有统计学意义(P<0.01);是否转移,转移比未转移的表达量低,差异具有统计学意义(P<0.01)。GRIM-19蛋白在病理分级、临床分期及中是否转移的表达情况,均呈正相关。结论:GRIM-19可以作为判定膀胱癌的预后的一个标准。

Objective：To investigate the relationship of the cells Grim-19expression with pathological grade and clinical stage of bladder cancer.Methods：Western blot methods were used to detect the expression of GRIM-19in cancer tissues and para-carcinoma tissue of 50patients with bladder cancer and normal tissues of 38cases.The relationship of these indicators with bladder cancer pathological grade and clinical stage was analyzed.Results：There was significant difference in GRIM-19expression among cancer tissue,para-carcinoma tissue and normal bladder tissue difference（P0.01）,the difference was also significant between cancer tissue and para-carcinoma tissue（P0.05）.The expression was significantly decreased as declining clinical stage（P0.01）;expression at clinical stage T2to T4was significantly higher than it at Tis-T1（P0.01）;the expression was significantly lower in cases with metastasis（P0.01）.GRIM-19protein expression was positively correlated with pathological grade,clinical stage and metastasis.Conclusion：GRIM-19can be used as an indicator for determination of bladder cancer prognosis.