摘要
目的:探讨细胞GRIM-19在膀胱癌组织中的表达及与病理分级和临床分期之间的关系。方法:采用Westernblot方法分别检测50例膀胱癌患者膀胱癌组织、癌旁组织及38例正常膀胱组织中GRIM-19的表达情况,进行分析上述指标与膀胱癌病理分级和临床分期的关系。结果:显示GRIM-19膀胱癌、癌旁组织中的表达与正常膀胱组织比较,差异有统计学意义(P<0.01),膀胱癌、癌旁组织中的表达比较,差异具有统计学意义(P<0.05)。膀胱癌、癌旁组织中的表达:临床分级,Ⅰ级逐渐向Ⅲ级下降,差异具有统计学意义(P<0.01);临床分期,T2~T4高于Tis~T1,差异具有统计学意义(P<0.01);是否转移,转移比未转移的表达量低,差异具有统计学意义(P<0.01)。GRIM-19蛋白在病理分级、临床分期及中是否转移的表达情况,均呈正相关。结论:GRIM-19可以作为判定膀胱癌的预后的一个标准。
Objective:To investigate the relationship of the cells Grim-19expression with pathological grade and clinical stage of bladder cancer.Methods:Western blot methods were used to detect the expression of GRIM-19in cancer tissues and para-carcinoma tissue of 50patients with bladder cancer and normal tissues of 38cases.The relationship of these indicators with bladder cancer pathological grade and clinical stage was analyzed.Results:There was significant difference in GRIM-19expression among cancer tissue,para-carcinoma tissue and normal bladder tissue difference(P0.01),the difference was also significant between cancer tissue and para-carcinoma tissue(P0.05).The expression was significantly decreased as declining clinical stage(P0.01);expression at clinical stage T2to T4was significantly higher than it at Tis-T1(P0.01);the expression was significantly lower in cases with metastasis(P0.01).GRIM-19protein expression was positively correlated with pathological grade,clinical stage and metastasis.Conclusion:GRIM-19can be used as an indicator for determination of bladder cancer prognosis.
出处
《海南医学院学报》
CAS
2013年第10期1372-1374,共3页
Journal of Hainan Medical University
基金
海南省科技厅(811210)~~