弥散张量纤维束成像技术在胼胝体轴索损伤中的应用

Application of diffusion tensor tractography in axonal injury of corpus callosum

目的探讨弥散张量纤维束成像技术在胼胝体轴索损伤中的应用价值。方法 40例临床确诊为轴索损伤的患者(轴索损伤组)及与其年龄、性别及教育背景相似的志愿者40例(对照组),分别行常规序列及弥散张量序列扫描及纤维束重建技术。重建2组胼胝体纤维束图像,比较2组胼胝体纤维束的形态、结构变化情况。结果对照组纤维束显示清晰、致密;轴索损伤组胼胝体纤维束变薄、稀疏、中断甚至缺失。结论弥散张量纤维束成像技术可直观显示胼胝体的损伤部位及程度,对于轴索损伤病灶的检出及病情的评价具有重要的意义。

Objective To explore the value of diffusion tensor tractography（DTT） in axonal injury of corpus callosun.Methods Forty patients with axonal injury were selected as axonal injury group,and 40 volunteers who had the similar age,sex and educational background were selected as control group.The sequence scan and fiber bundles reconstruction technique of the conventional magnetic resonance imaging（MRI） and diffusion tensor imaging（DTI） were used in all cases.The changes of the form and structure of corpus callosum fiber bundles were compared between the two groups according to the fiber bundles picture of the corpus callosum.Results The corpus callosun fiber bundles of the control group was clear and dense,while the fibers were few,scattered,interrupted or even absent in axonal injury group.Conclusion DTT can show the site and degree of injury of fiber bundles,and plays an important role in detecting the focus of axonal injury and evaluating the patient′s condition.