盐酸川芎嗪注射液联合红花注射液治疗不稳定型心绞痛疗效观察

Ligustrazine hydrochloride combined with safflower injection for treating unstable angina pectoris

目的探讨盐酸川芎嗪注射液联合红花注射液治疗不稳定型心绞痛(UAP)的临床效果。方法 97例UAP患者分为2组,观察组49例给予盐酸川芎嗪注射液和红花注射液联合治疗,对照组48例给予川芎嗪注射液治疗,对比观察2组患者的治疗效果。结果观察组患者治疗总有效率显著高于对照组(P<0.05);2组患者治疗前心率、血压比较差异均无统计学意义(P>0.05);观察组患者治疗后心率、收缩压和舒张压均显著低于治疗前(P<0.05);对照组患者治疗后心率和收缩压显著低于治疗前(P<0.05),但治疗前后舒张压比较差异无统计学意义(P>0.05);治疗后观察组患者心率和血压显著低于对照组(P<0.05)。结论盐酸川芎嗪注射液和红花注射液联合治疗UAP,效果优于单纯应用川芎嗪注射液。

Objective To investigate the effect of ligustrazine hydrochloride injection combined with safflower injection in treatment of patients with unstable angina pectoris（UAP）.Methods Ninety-seven patients with UAP were divided into two groups,forty-nine patients in observation group were treated with ligustrazine hydrochloride injection and safflower injection,forty-eight patients in control group were treated with ligustrazine hydrochloride injection,the therapeutic effects were observed and compared between the two groups.Results The total effective rate in observation group was significantly higher than that in control group（P0.05）.There was no significant difference in heart rate and blood pressure before treatment between the two groups（P0.05）.In observation group,the heart rate,systolic blood pressure and diastolic blood pressure after treatment were significantly lower than those before treatment（P0.05）.In control group,the heart rate and systolic blood pressure after treatment were significantly lower than those before treatment（P0.05）,but there was no significant difference in diastolic blood pressure pre-and post-treatment（P0.05）.After treatment,the heart rate and blood pressure in observation group were significantly lower than those in control group（P0.05）.Conclusion Ligustrazine hydrochloride injection and safflower injection in treatment of patients with UAP is more effective than the simple application of ligustrazine injection.