自动固相微萃取-气相色谱/串联质谱法测定饮用水中11种邻苯二甲酸酯

Determination of eleven phthalate esters in drinking water by automated solid phase micro-extraction coupled with gas chromatography-triple quadrupole mass spectrometry

目的:建立自动固相微萃取(SPME)-气相色谱/三重四极杆串联质谱法(GC-QqQ-MS/MS)分析饮用水中11种痕量邻苯二甲酸酯类化合物(PAEs)的方法。方法:选用85μm聚丙烯酸酯(PA)萃取纤维,在CTC全自动固相微萃取装置上,对水样中的PAEs自动萃取富集,然后插入GC进样口,在270℃下解吸后,采用气相色谱/三重四极杆串联质谱在多反应监测(MRM)模式下进行外标法定量测定。结果:11种PAEs的检出限为0.0004μg/L^0.06μg/L,回收率为79.3%~129.0%,相对标准偏差为6.8%~22.7%(n=5)。结论:本方法简便、快速、灵敏,能同时准确定性定量测定饮用水中11种邻苯二甲酸酯。

Objective： To develop a method for the determination of 11 phthalate esters in drinking water by au- tomated solid phase micro - extraction and gas chromatography - triple quadrnpole mass spectrometry. Methods： The PAEs in water were extracted using polyacrylate （PA） fiber, and then the fiber was introduced into the GC injector port and the extracts were desorbed at 270 ℃ with CTC automated solid phase micro - extraction device. The detection of 11 PAEs was carried out by GC - QqQ - MS/MS in the multi - reaction monitoring （MRM） mode and quantified using external standard method. Results： The detection limits ranged from 0. 0004 μg/L - 0.06 μg/L with recoveries of 79.3% - 129.0% and relative standard deviations of 6.8% -22.7% （n = 5 ）. Conclusion ： The method is simple, rapid, sensitive, and it is suitable for qualitative and quantitative determination of 11 phthalates in drinking water,