利克飞龙的抗炎作用研究

Anti-inflammatory effects of licofelone

目的研究利克飞龙的抗炎作用。方法通过ig给药,观察利克飞龙对大小鼠的抗炎活性以及炎性因子水平。结果 ig利克飞龙(60mg/kg)对小鼠耳肿胀及角叉菜胶引起大鼠足趾肿胀抑制作用与甲泼尼龙(60mg/kg)相当,利克飞龙给药一周对小鼠体质量正常生长没有影响,利克飞龙对炎性因子前列腺素E2(PGE2)含量降低作用与塞来昔布相当。结论利克飞龙具有高效的抗炎作用,其抗炎作用与甲泼尼龙相当,其降低PGE2作用与塞来昔布相当,且利克飞龙为COX/5-LOX双靶标抑制剂,理论上安全性更高,患者可长期服用,有望成为临床上非甾体抗炎药中的首选药物之一。

Objective To study the anti-inflammatory effect of licofelone. Methods By ig administration, anti-inflammatory activity and inflammatory factor levels of licofelone were observed. Results The inhibition of licofelone （60 mg/kg） on ear swelling of mice and carrageenan-induced paw edema of rats were similar to those of methylprednisolone （60 mg/kg）. Licofelone treatment for one week did not affect the normal growth of the body weight of mice. The decreasing of inflammatory factor PGE 2 by licofelone was similar to that of celecoxib. Conclusion Licofelone has high anti-inflammatory effect, which is equivalent to that of methylprednisolone, and its anti-PGE 2 effect is equivalent to that of celecoxib. Licofelone is an inhibitor for COX/5-LOX dual target, theoretically more secure, and could be long-term used in patients. It is expected to become one of the preferred drugs of non-steroidal anti-inflammatory drugs in clinic.