新密市妇幼保健院干预前后清洁手术围术期预防性应用抗菌药物合理性分析

Analysis of Rationality in Perioperative Use of Prophylactic Antibiotics for Patients Undergoing Aseptic Operation in Xinmi Maternal and Child Health Care Hospital before and after Intervention

目的:评价我院对清洁手术围术期预防性应用抗菌药物干预的效果。方法:将2010年5月—2012年5月我院普外科400例清洁手术患者分为非干预组和干预组,根据抗菌药物合理应用评价标准,对其应用情况、合理性评价结果及费用等进行对比分析。结果:干预组围术期抗菌药物使用合理率为94.5%(189/200),显著高于非干预组的28.5%(57/200)(P<0.01);干预组抗菌药物使用率为16%(32/200),显著低于非干预组的93%(186/200)(P<0.01);干预组人均抗菌药物费用为28.52元,显著低于非干预组的424.56元(P<0.01);干预组平均住院时间为6.44 d,明显低于非干预组的7.79 d(P<0.05)。结论:我院对清洁手术围术期抗菌药物使用的一系列干预措施收效显著,对促进医院安全、有效、经济地使用抗菌药物起到了积极作用。

OBJECTIVE： To evaluate the intervention efficacy on perioperative use of antibiotics in patients undergoing aseptic operation in our hospital METHODS： 400 patients from department of general surgery in our hospital undergoing aseptic operation from May 2010 to May 2012 were assigned to either non-intervention group and intervention group. The evaluation results on the use of antibiotics and its rationality and cost were analyzed contrastively according to evaluation criteria for rational use of antibiotics. RESULTS： Compared with the non- intervention group, the intervention group had significantly higher rate of rational use of antibiotics [ 94. 5% （189/ 200） vs. 28.5% （57/200） （P 〈0.01） ], significantly lower rate of antibiotic use [ 16% （32/200） vs. 93% （186/ 200） （P 〈 0.01 ） ] , significantly lower average antibiotic cost （28.52 yuan vs. 424.56 yuan, P 〈 0. 01 ）, significantly less average hospital stay （6.44 days vs. 7.79 days, P 〈0.05）. CONCLUSION： The series intervention measures aimed at perioperative use of antibiotics in patients undergoing aseptic operation in our hospital achieved remarkable efficacy and which are conducive to safe, effective and economical antibiotic use.