287例药品不良反应报告分析

Analysis of 287 Adverse Drug Reaction Cases

目的:了解药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:收集2011—2012年我院上报的287例ADR报告,按患者性别、年龄、给药途径、涉及药品种类、累及器官和(或)系统及临床表现等进行统计分析。结果:287例发生ADR的患者中,60岁以上者居首位,为126例,占43.90%;引发ADR的给药途径以静脉滴注为主,为150例,占52.26%;由抗感染药引发的ADR最多,为73例,占25.44%;ADR累及器官和(或)系统以皮肤及附件损害最常见,为98例次,占总共302例次数的32.45%。结论:临床应该重视ADR监测和报告工作,合理用药,以减少ADR的发生。

OBJECTIVE：To investigate the characteristics and regular patterns of adverse drug reaction （ADR） in our hospital for clinical reference of rational use of drug. METHODS： 287 ADR cases reported by our hospital from 2011 to 2012 were analyzed statistically in terms of patients＇ sex, age, route of administration, drug variety, organs and （or） systems involved in ADR and clinical manifestations etc. RESULTS： Of the total 287 cases, patients aged above 60 years old showing the highest proportion at 43.90% （126 cases ）; most of the ADR were induced by intravenous drip infusion, accounting for 52.26% （ 150 cases） ; most of the ADR were induced by anti-infective drugs, accounting for 25.44% （73 cases） ; the ADR manifested mostly as damage of skin and appendants, accounting for 35.19% （98/302）. CONCLUSION： Importance should be attached to ADR report and monitoring. Rational use of dru^s should be emnhasized to reduce, the occurrence of ADR.