195例Ⅰ类切口手术预防性应用抗菌药物分析

Perioperative Use of Prophylactic Antibiotics in Patients Undergoing TypeⅠOperation: Analysis of 195 Cases

目的:了解Ⅰ类切口手术围术期抗菌药物应用情况,为抗菌药物的合理应用及其监督管理提供参考依据。方法:回顾性调查分析甲状腺手术、乳腺手术、腹外疝术共计195例患者抗菌药物的使用情况。结果:195例患者围术期抗菌药物使用率为71.8%(140/195);使用较多的抗菌药物为头孢菌素类,其中使用频次居首位的为头孢唑林钠,有126例患者使用该药,占90.0%(126/140)。术前0.5～2 h内给药者121例,术前15 min给药者2例,术后给药者17例;术后1 d内停药者44例,术后2 d内停药者10例,术后>2 d停药者76例。结论:195例Ⅰ类切口手术围术期预防性应用抗菌药物存在不合理用药情况,主要表现为用药指征掌握不严、选药不当、给药时间不适宜、用药疗程过长等。

OBJECTIVE ：To investigate the perioperative use of prophylactic antibiotics in patients undergoing type I incision operation so as to provide references for rational use and supervisory management of antibiotics. METHODS ： By a retrospectively study, the antibiotic use in 195 patients undergoing operations of mammary gland, thyroid gland or external abdominal hernia were analyzed retrospectively. RESULTS： Of the total 195 patients, the rate of perioperative antibiotic use was 71.8% （140/195）. Cephalosporins were used most frequently, with eefazolin topping the list （used in 126 cases, accounting for 90. 0% ）. Antibiotics were administered within 0.5-2 h before operation in 121 cases, 15 minutes before operation in 2 cases and after operation in 17 cases. Antibiotics were discontinued within first postoperative day in 44 cases, within second postoperative day in 10 cases, and after second postoperative day in 76 cases. CONCLUSION： Non-rational use of prophylactic antibiotics was noted in the 195 patients undergoing typeIincision operation. The irrationality manifested as non-strict mastering of the medication indication, improperly choice of the antibiotics, inappropriate administration occasion, and prolonged administration duration.