血清胱抑素C对新生儿窒息后肾损伤诊断价值的Meta分析

A meta-analysis of the diagnostic value of Serum cystatin C in kidney injury induced by Asphyxia newborn

目的探讨血清胱抑素C(cys C)对新生儿窒息后肾功能损伤的诊断价值。方法检索PubMed、Ovid、Springer数据库、中国期刊全文数据库、万方数据库和维普数据库的在库文献,按照诊断试验的纳入标准筛选文献,提取纳入研究的特征信息。数据分析采用RevMan 5.1软件,检验异质性并根据结果选择相应效应模型进行Meta分析。结果按照纳入标准,最终获得23篇文献。经Meta分析结果表明轻度窒息组和重度窒息组的血清cys C水平比对照组的分别高1.66(1.35～1.97)和3.78(3.23～4.34)倍标准差,而重度窒息组的血清cys C水平比轻度窒息组的高2.05(1.61～2.48)倍标准差,说明窒息新生儿的血清cys C水平比健康新生儿的高,且窒息程度越严重,血清cys C水平越高。结论血清cys C的水平有助对窒息新生儿肾功能损伤的早期诊断及严重程度的评价。

Objective To explore the diagnosis value of the serum cystatin C in kidney injury induced by Asphyxia newborn.Methods To search PubMed,Ovid,Springer Database,Chinese Academic Journal,VIP Database and Wanfang database in the library literature,according to the inclusion criteria of diagnostic tests to screen documents,and extract the characteristic information included in the study.Using RevMan5.1 software to anaylsis the data,according the results of tests for heterogeneity to select the effects model and carry out meta analysis.Results According to the inclusion criteria,it was won the 23 articles eventually.The Meta analysis results showed the serum cys C levels of light asphyxia group and severe group were 1.66（1.35~1.97） and 3.78（3.23~4.34） times the standard deviation higher than the control group（healthy newborns） and the serum cys C levels of severe asphyxia group was 2.05（1.61~2.48） times the standard deviation higher than light asphyxia group,to explain that the serum cys C levels of neonatal asphyxia higher than healthy neonatal,and the more serious of neonatal asphyxia,the higher of the serum cys C levels.Conclusion the serum cys C levels contribute to the early diagnosis and severity assessment in kidney injury induced by Asphyxia newborn.