卵巢癌FIGO分期与血小板计数相关性分析

Correlation between the ovarian cancer FIGO stage and platelet count

目的探讨血小板计数变化与卵巢癌分期的关系。方法选取2009年1月至2010年8月有明确病理分型及血细胞分析结果的卵巢癌患者74例(其中16例淋巴结转移),并与68例良性卵巢癌患者结果进行比较。结果早期卵巢癌组、晚期卵巢癌组和对照组间PLT计数两两比较差异均有统计学意义(P<0.05)。晚期卵巢癌PLT增多所占比例明显高于早期卵巢癌组,差异有统计学意义(P<0.05)。卵巢癌早、晚期手术前PLT值较高,手术后显著下降(P<0.05)。13例经标准治疗后,由稳定发展至转移的患者,稳定期与转移期血小板值比较差异有统计学意义(P<0.05)。结论卵巢癌常可观察到PLT增多现象,随着分期升高,PLT增高所占比例也随之增加,同时PLT增多可能对卵巢癌发展和转移评估有一定的意义。

Objective The aim of the present study was to investigate the correlation between platelet count and the stage of ovarian cancer（FIGO）.Methods Medical records of 74 ovarian cancer patients between January 2009 and August 2010 were reviewed.Clinicopathological and complete blood count data were collected.The results were compared with those of 68 patients with benign ovarian tumor.16 patients who had surgeon have metastasis.Results We found that platelet count in pretreated ovarian cancer patients was distinctively higher than patients with benign ovarian tumor（P0.05）,significantly higher in late stage than in early stage（P0.05）,and significantly lower after operation than before operation（P0.05）.After treatment,13 patients with higher platelet count are easier metastasis than those of normal platelet count.Conclusion Preoperative thrombocytosis is a frequent finding in ovarian cancer and their association with advanced stage disease and higher grade denotes that platelets perhaps play a role in the tumor growth and metastasis.