1818例泌尿生殖道支原体感染检测及药敏分析

1818 cases detection on genitourinary tract mycoplasma infection and analysis of resistance

目的了解佛山地区泌尿生殖道感染者支原体感染率及耐药情况,指导临床合理用药。方法使用支原体分离培养、鉴定、药敏试剂盒对泌尿生殖道支原体培养标本进行解脲脲原体(Uu)和人型支原体(Mh)检测及药敏试验。结果 1 818例患者中支原体阳性456例,感染率为25.1%,其中Uu、Mh以及Uu+Mh混合感染的阳性率分别为19.3%、1.0%和4.8%,两两比较,差异有统计学意义(P<0.01)。药敏结果表明:Uu、Mh、Uu合并Mh感染对交沙霉素、强力霉素、美满霉素均较为敏感。结论佛山地区泌尿生殖道支原体感染以Uu为主,交沙霉素等对Uu、Mh、Uu合并Mh感染敏感性较好。临床用药应根据支原体的种类和药物敏感性进行选择。

Objective To investigate the prevalence rate of Mycoplasma infection and drug resistance from patients with genitourinary tract infection in Foshan to guide clinical medicine use.Methods The isolation and susceptibility tests of Ureaplasma urealyticum（Uu）and Mycoplasma hominis（Mh） were performed with kits for culture,identification and counting.Results 456 of 1 818 cases were infected with mycoplasma,the total positive rate was 25.1%,the positive rates of Uu,Mh and their mixed infection rate were19.3%、1.0%and 4.8%.There was significant difference between each two groups（P0.01）.The mixed infection of Uu,Mh and Uu with Mh was more sensitive to Josamycin,Doxycycline,and Minocycline than other antibiotics.Conclusion Uu is the major pathogen of mycoplasma infection in genitourinary tract.Uu,Mh and Uu with Mh are more sensitive to Josamycin,etc.The results obtained indicate that we should select antimicrobial agents according to the results of culture and antimicrobial susceptibility.