摘要
目的观察复方苦参注射液联合化疗治疗晚期非小细胞肺癌(NSCLC)的疗效和毒副反应。方法将晚期NSCLC患者76例随机分为2组。治疗组(40例)采用常规化疗联合复方苦参注射液;对照组(36例)采用单纯化疗。观察2组患者的近期疗效、生活质量、血液学毒性及生存状况等。结果治疗组与对照组有效率分别为45.0%和38.9%,差异无统计学意义(P>0.05);临床获益率分别为72.5%和47.2%,差异有统计学意义(P<0.05)。生活质量总改善率治疗组75.0%,高于对照组的47.2%(P<0.05)。1 a生存率治疗组43.3%,高于对照组的30.9%(P<0.05)。治疗组血液学毒性治疗前后比较差异无统计学意义(P>0.05);对照组血液学毒性治疗前后比较差异有统计学意义(P<0.05)。结论复方苦参注射液联合化疗治疗晚期NSCLC具有增效减毒的作用。
Objective To evaluate the efficacy and toxicities of combined kushen injection combined with chemotherapy in the treatment of advanced non-small celt lung cancer (NSCLC). Methods Seventy-six patients with advanced NSCLC were divided into two groups,40 cases of the treatment group) were treated with kushen injection combined with chemotherapy ,and 36 cases of of the control group were treated with chemotherapy alone. The shortterm therapeutic effect, quality of life, hematological toxicities, survival were observed. Results The response rate of the treatment group was 45.0,and was 38.9 of the control group (P 〉0.05) ; the clinical benefit rate were 72.5% and 47.2% , respoctively (P 〈 0.05 ) ; the improvement rate of quality of life were 75.0% and 47.2%, respectively ( P 〈 0.05 ) ; the 1 -year survival rate were 43.3% and 30.9% , respectively ( P 〈 0.05 ). There was no statistical difference in the hematological toxicities of the treatment group before and after treatment ( P 〉 0.05 ). There were statistical differences in the hematological toxicities of the control group before and after treatment ( P 〉 0.05 ). Conclusion kushen injection combined with chemotherapy is effect and hannfulless.
出处
《肿瘤基础与临床》
2013年第4期308-310,共3页
journal of basic and clinical oncology
关键词
复方苦参注射液
化疗
非小细胞肺癌
kushen injection
chemotherapy
non-small cell lung cancer