摘要
帕金森病是中老年人常见的神经变性疾病,以黑质致密部多巴胺能神经元进行性缺失、纹状体多巴胺水平降低为主要特点。中枢神经系统炎症和全身炎症都会导致多巴胺能神经元变性和死亡;抑制中枢神经炎症,靶向调节全身炎症、减轻外周损伤对大脑的影响,有助于缓解和阻止病情的发展,给帕金森病的预防和治疗提供新思路。
Parkinson’s disease is a common progressive neurodegenerative disorder among old people,characterized by progressive loss of dopamine-producing neurons in the substantia nigra pars compacta and accordingly low level of dopamine in the nigrostriatal pathway.Neuroinflammation and even systemic inflammation have been suggested to be involved in the demise of dopaminergic neurons.Anti-inflammatory treatment could protect brain from inflammatory injury and prevent the progressive course of Parkinson’s disease,which suggests a potential new strategy for Parkinson’s disease treatment.
出处
《中国康复理论与实践》
CSCD
北大核心
2013年第7期640-644,共5页
Chinese Journal of Rehabilitation Theory and Practice
基金
科技部"十二五"重大创新药专项(No.2012ZX09102-201-016)
国家自然科学基金(No.81173575)
国家自然科学基金(No.30740053)
北京市自然科学基金(No.7062031)
北京市教委科研基地-科技创新平台(No.111219)
北京市卫生系统高层次卫生技术人才(No.2011-3-097)
关键词
帕金森病
神经炎症
全身炎症
综述
Parkinson’s disease
neuroinflammation
systemic inflammation
review