复方斑蝥胶囊联合FOLFOX4方案对晚期消化道恶性肿瘤患者免疫功能及生活质量的影响

Effect of Complex Banmao Capsules Combined with FOLFOX4 Regimen on Immune Function and Quality of Life in Advanced Gastrointestinal Malignancies Patients

目的:观察复方斑蝥胶囊联合FOLFOX4方案对晚期消化道恶性肿瘤的临床疗效。方法:将符合纳入标准的120例晚期消化道恶性肿瘤患者随机分为单纯化疗组与联合治疗组各60例。两组均给予FOLFOX4方案进行化疗,联合治疗组同时给予复方斑蝥胶囊1 g/次,3次/d,连用4周。结果:卡氏评分(KPS)改善率治疗组58.3%,单纯组33.3%,两组差异显著(P<0.05);肿瘤患者CD4+T淋巴细胞、自然杀伤细胞(NK)细胞数低于健康对照组,CD8+T淋巴细胞高于健康对照组(P<0.05);联合治疗组治疗后外周血CD4+T淋巴细胞、NK细胞[CD4+(42.8±8.2)%,NK(22.1±3.5)%]较单纯组[CD4+(37.8±7.6)%,NK(16.7±5.3)%]升高更明显,且差异有统计学意义(P<0.05),CD8+T细胞亚群数下降更明显[CD8+(25.4±3.4)%vs(27.6±6.2)%],且差异有统计学意义(P<0.05)。治疗组试验组化疗毒副反应较轻,与单纯组比较差异有统计学意义(P<0.05)。结论:晚期消化道恶性肿瘤患者免疫功能低下。FOLFOX4方案治疗可使受抑制的细胞免疫功能部分恢复,服用复方斑蝥胶囊可使细胞免疫功能进一步提高,同时能提高患者的生活质量,减轻化疗的毒副反应。

Objective： To observe the effect of complex Banmao regimen in the treatment of advanced gastrointestinal malignancies patients capsules combined with FOLFOX4 Method： One hundren and twenty cases with advanced gastrointestinal malignancies were randomly divided into treatment group and simple group with 60 cases in each group. The two groups were given FOLFOX4 regimen. The treatment group was additionally given complex Banmao capsules （1 g, Tid） for 4 weeks. Result： The karnofsky performance status （KPS） improvement rate in treatment group was 58.3% , while in simple group was 33.3%, two groups had significant difference （ P 〈 0. 05 ）. All patients with advanced gastrointestinal malignancies showed that the CD4 ＋ T cells and natural killer （NK） cells were lower than that of the controlled group （P 〈0. 05） , the CD8 ＋T cells were higher than those of the control group （P 〈 0.05）. After treatment the CD4 ＋ T cells and NK cells in the treatment group [CD4＋ （42. 8± 8.2）%, NK （22. 1 ± 3.5）% ] was increased more significantly than simple group [ CD4＋ （37.8±7.6）%, NK （16.7±5.3）%] （P〈0.05）. After treatment the CD8 ＋ T cells in the treatment group were decreased more significantly than simple group [ CD8 ＋ （25.4 ± 3.4） % vs （27.6± 6.2） % ] （P 〈 0. 05 The incidence of toxicity after chemotherapy in the treatment group was lower than simple group （ P 〈 0.05Conclusion： The cellular immunological functions were inhibited in patients with advanced malignancies. FOLFOX4 regimen could reverse the immune suppression state in patients gastrointestinal malignancies. The combination of FOLFOX4 regimen and Fufang Banmao remarkably improve immunological functions, quality of life and reduce toxicity after FOLFOX4 advanced gastrointestinal malignancies patients. gastrointestinal with advanced Capsules could chemotherapyin