长春瑞滨联合顺铂治疗非小细胞肺癌

Treatment of non small cell lung cancer with vinorelbine plus cisplatin

观察长春瑞滨 (诺维本 ,NVB)联合顺铂 (DDP)治疗非小细胞肺癌的疗效。方法 :6 0例患者分别用NP(NVB加DDP)方案和MNP[丝裂霉素 (MMC)联合NVB与DDP]方案治疗。结果 :NP和MNP组有效率分别为42 9% (12 2 8)和 46 9% (15 32 ) ,两者无显著差异 (P >0 0 5 )。分析诸多因素对疗效的影响发现 ,病期早较病期晚疗效好 ,鳞癌比腺癌疗效好。骨髓抑制为限制性毒性 ,白细胞下降NP组为 82 1% ,MNP组为 87 5 % ,P >0 0 5 ,无其他严重毒副反应。结论 :治疗非小细胞肺癌 ,NP方案能获得与MNP方案相似的疗效 。

Purpose:To observe the therapeutic effects of vinorelbine (NVB) plus cisplatin (DDP) (NP regimen) for the treatment of non small cell lung cancer (NSCLC). Methods:60 cases were treated with NP (NVB plus DDP) or MNP[mitomycin (MMC) plus NVB and DDP] regimen. Results:Response rates were 42.9% (12/28) and 46.9%(15/32),respectively for these two regimens. No statistical difference was noted in responses between these two groups (P>0 05). Neutropenia was the dose limiting toxicity and occurred in 82.1% of cases in the NP regimen and 87.5% in the MNP regimen (P>0 05). No other serious side reactions occurred in either groups. Conclusions:The NP regimen can obtain results just as good as with the MNP regimen in the treatment of NSCLC.