Hp相关性十二指肠溃疡患者胃泌素、生长抑素变化及其意义

Alterations of Gastrin and Somatostatin Contents in Duodenal Ulcers with Helicobacter Pylori Infection

目的 :探讨幽门螺杆菌 (Hp)相关性十二指肠溃疡 (DU)患者的胃粘膜及血浆中胃泌素 (SS)、生长抑素(GAS)的变化及其意义。方法 :对 45例证实为Hp感染的DU患者 ,采用PPI三联疗法 ,1月后胃镜复查。同时采用放射免疫法检测治疗前后血浆和胃粘膜中GAS、SS的表达 ,并与对照组比较。结果 :治疗后①溃疡愈合率为 86 .7% ,Hp根除率达 91.1% ;②血浆和胃粘膜中GAS、SS含量与对照组差异无显著性 (P >0 .0 5 ) 。但两组的GAS、SS较治疗前差异均有显著性 (P <0 .0 1)。结论 :Hp感染后胃粘膜及血浆中GAS分泌增加、SS分泌减少 ,是引起DU的原因之一。Hp根除后GAS、SS均可恢复正常水平。

Objective:To investig ate the alterations of GAS and SS contents in duodenal ulcers with Hp infection and study their significance.Methods:Before and after triple therapy,the radioimmune method was employed to assay the contents of gastrin and somatostatin in plasma and gastric mucosa of the 45 duodenal ulcer patients with Hp infection.Results:One month after triple therapy,① the cure rate of ulcers was 86.7%,and the eradicating rate of Hp was 91.1%;② The gastrin and somatostatin both in plasma and gastric mucosa were normal but significantly different from those before therapy.Conclusion:The infection of Hp may hinder thd physiological secretion of somatostatin and gastrin,which is a significant step in the development of duodenal ulcers.