三黄膏调合蜂蜜对放疗患者放射性皮肤损伤的防治效果观察

Preventive and Therapeutic Efficacy of Sanhuang Plaster Blending with Honey for Radiation-induced Skin Injury

目的:观察三黄膏调合蜂蜜对放疗患者放射性皮肤损伤的防治效果。方法:将食管癌放疗过程中出现放射性皮肤损伤的患者100例,随机分为对照组与观察组各50例。对照组在放疗后皮肤损伤处先使用无菌生理盐水清洗,再用无菌棉签均匀地涂抹三乙醇胺乳膏于创面之上,厚度约为2mm,每天2次;观察组清洗创面后涂抹三黄膏调合蜂蜜(三黄膏与蜂蜜的比例为3∶1,m/m),厚度约为2mm,每天2次。比较两种方法对放疗患者放射性皮肤损伤的防治效果。结果:治疗后两组患者的放射性皮肤损伤均较治疗前明显好转,其中对照组放射性皮炎转为0～Ⅱ级的患者有34例,构成比为68.00%,观察组放射性皮炎转为0～Ⅱ级的患者有46例,构成比为92.00%,两组比较差异具有统计学意义(P<0.01);观察组用药后接受辐照剂量≥20Gy才会发生皮肤反应,而对照组在辐照很小剂量时就可发生皮肤反应,两组比较差异具有统计学意义(P<0.01)。结论:三黄膏调合蜂蜜对放疗患者放射性皮肤损伤的防治效果较佳。

OBJECTIVE： To investigate the preventive and therapeutic efficacy of Sanhuang plaster blending with honey for ra- diation-induced skin injury. METHODS： 100 patients with radiation-induced skin injury during radiotherapy of esophageal cancer were randomly divided into control group and observation group with 50 cases in each group. The regions of skin lesions were cleaned with sterile normal saline in control group after radiotherapy, and then evenly applied Triethanolamine ointment on the wound with the thickness of 2 mm about, twice a day; observation group applied Sanhuang plaster blending with honey （ratio of Sanhuang piaster to honey 3 ： 1, m/m） on the wound with thickness of 2 mm, twice a day. Preventive and treatment efficacy of 2 methods for radiation-induced skin injury were compared. RESULTS： After treatment, radiation-induced skin injury of 2 groups were improved significantly; there were 34 patients with 0-Ⅱ grade radioactive dermatitis in control group, with constituent ratio of 68.00% ; there were 46 patients with 0- Ⅱ grade radioactive dermatitis in observation group, with constituent ratio of 92.00% ; there was statistical significance（P〈0.01）. The skin reaction was caused in observation group after radiated with radiation dose≥ 20 Gy and in control group after radiated with little radiation dose; there was statistical significance（P〈0.01）. CONCLUSIONS： Sanhuang plaster blending with honey gets better results in the treatment of radiation-induced skin injury.